Tag | Content |
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UniProt Accession | GSK3B_MOUSE; Q9WV60; |
Entrez ID | 56637 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) |
Gene Name | Gsk3b |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and h(view all) |
Sequence (Fasta) | MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR PQEVSYTDTK 60 VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI MRKLDHCNIV RLRYFFYSSG 120 EKKDEVYLNL VLDYVPETVY RVARHYSRAK QTLPVIYVKL YMYQLFRSLA YIHSFGICHR 180 DIKPQNLLLD PDTAVLKLCD FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV 240 WSAGCVLAEL LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300 WTKVFRPRTP PEAIALCSRL LEYTPTARLT PLEACAHSFF DELRDPNVKL PNGRDTPALF 360 NFTTQELSSN PPLATILIPP HARIQAAASP PANATAASDT NAGDRGQTNN AASASASNST 420 421 |
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Database | Annotation |
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CTD (Curated) (count: 20) (view all) | MESH:D000015
; Abnormalities, Multiple MESH:D058186 ; Acute Kidney Injury MESH:D000544 ; Alzheimer Disease MESH:D001169 ; Arthritis, Experimental MESH:D001714 ; Bipolar Disorder MESH:D001930 ; Brain Injuries |
PTM | Modification Sites |
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Phosphorylation (count: 14) (view all) | 13 RTTSFAESCKPVQQP dbPAF
21 CKPVQQPSAFGSMKV dbPAF 215 VRGEPNVSYICSRYY dbPAF 216 RGEPNVSYICSRYYR dbPAF 219 PNVSYICSRYYRAPE dbPAF 25 QQPSAFGSMKVSRDK dbPAF |
Network | Interaction | ||
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A | B | Source | |