Tag | Content |
---|---|
UniProt Accession | STK11_MOUSE; Q9WTK7; |
Entrez ID | 20869 |
GenBank Protein ID | NM_001301853.1; NM_001301854.1; NM_011492.4; |
GenBank Nucleotide ID | NP_001288782.1; NP_001288783.1; NP_035622.1; |
Protein Name | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1) (mLKB1) |
Gene Name | Stk11; Lkb1 |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53(view all) |
Sequence (Fasta) | MDVADPEPLG LFSEGELMSV GMDTFIHRID STEVIYQPRR KRAKLIGKYL MGDLLGEGSY 60 GKVKEVLDSE TLCRRAVKIL KKKKLRRIPN GEANVKKEIQ LLRRLRHRNV IQLVDVLYNE 120 EKQKMYMVME YCVCGMQEML DSVPEKRFPV CQAHGYFRQL IDGLEYLHSQ GIVHKDIKPG 180 NLLLTTNGTL KISDLGVAEA LHPFAVDDTC RTSQGSPAFQ PPEIANGLDT FSGFKVDIWS 240 AGVTLYNITT GLYPFEGDNI YKLFENIGRG DFTIPCDCGP PLSDLLRGML EYEPAKRFSI 300 RQIRQHSWFR KKHPLAEALV PIPPSPDTKD RWRSMTVVPY LEDLHGRAEE EEEEDLFDIE 360 DGIIYTQDFT VPGQVLEEEV GQNGQSHSLP KAVCVNGTEP QLSSKVKPEG RPGTANPARK 420 VCSSNKIRRL SACKQQ 437 |
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Database | Annotation |
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CTD (Curated) (count: 10) (view all) | MESH:D000230
; Adenocarcinoma MESH:C538231 ; Adenocarcinoma of lung MESH:D002294 ; Carcinoma, Squamous Cell MESH:D006973 ; Hypertension MESH:D017379 ; Hypertrophy, Left Ventricular MESH:D044483 ; Intestinal Polyposis |
PTM | Modification Sites |
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Phosphorylation (count: 13) (view all) | 156 PVCQAHGYFRQLIDG dbPAF
166 QLIDGLEYLHSQGIV dbPAF 261 PFEGDNIYKLFENIG dbPAF 31 TFIHRIDSTEVIYQP dbPAF 32 FIHRIDSTEVIYQPR dbPAF 325 ALVPIPPSPDTKDRW dbPAF |
Network | Interaction | ||
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A | B | Source | |