Q9V3N4

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	Q9V3N4_DROME; Q9V3N4;
Entrez ID	43392
GenBank Protein ID	NM_001276112.2; NM_143372.2;
GenBank Nucleotide ID	NP_001263041.1; NP_651629.1;
Protein Name	Huntingtin, isoform A (Huntingtin, isoform B) (Huntington disease protein homolog)
Gene Name	htt; dHtt; dhtt; DmelCG9995; DmHtt; HD; HsapHD; HTT; Htt; huntingtin; CG9995; Dmel_CG9995
Organism	Drosophila melanogaster
NCBI Taxa ID
Sequence (Fasta)	MDKSRSSAYD KFVGFVEQLR NTECSQKQKI TCFQQIAECI MSPSLAGHIN YAAHCGTATN 60 VLLLFCEDVD SVVRMSAEEN LNKILRSLEK TRVSRILMDL YGEIKRNGNQ RSLRICLNLF 120 SYYAPQIKEK HIKWYAVRLL QCMTTISQRK ETLLQETLCD FVKHFSRHIQ QGLSDSESCK 180 LFETFLDQIS SDCAVKRRCS AQNCMSLIEN ARNRSLMARH GVNKVMELLL TDQQANSVLG 240 ALGLLRLLLP QLIRGYPGDS HEDSESLAGK KQQQQQTTTS DCRQIIEIYD YCLHLLSTQH 300 TANHAIINAT LEVINGILQA VDAASDGQCS QSLGQSLRQL LCNQQLQHNE YLRRRKSLKN 360 QIFQLKNYEV ATSQHQLEDE DENEDVDELV VGATAMQMKK NSNAKLQQAK CREQQQHQHQ 420 QQLEVDNSSL GINAGEDAPT EAPSSVADEG GEPESTKLRC HIRNAARSIS ECVASDEDKQ 480 GQGHRQQRDE DGVVVAEDDD DDDDDDDDDD DMELLSAECD DFTTLSQLNE QQQALSAALK 540 LPTTTAASSG GAATSQDDKL IDVDADVGGL PKPQHQSSLQ NLLAGSDDKS QHLSDIDNES 600 FNSIDFDAEI TIAGSKEQQQ QHPPADDSVE SGDATAIGTF FNNLLSHSNA ASESVSKLFR 660 QSSGSKSTPS KSASTPAPAD KSDAISAASL TLSLTSLASS NLEPPERQPL IAETPTPVED 720 SCSITASHTA STALMMDAPA VEVAASKPET PQLRGTPNAN PFLVENSPLR QTVVGRALIT 780 VKIGSILEQS LVYYTARLVA ARFLLSGQAA GLQPDSISRV SIKSLSLAVI AQCVRLAPKI 840 LQLSLEISEQ ELQLLEEATS QIGSGDSTQV SSPQSSDNSQ VGGEKPPLDS SLVPTSLEEN 900 LLLLDIKDDH FGPSTCPAYL QSATPTLSRS ADASVLLLEG GTTSSRSAKK SEEMLSKSEI 960 IESSYRPTVA VEDVPPLSMP PRPPKRTKST RSRVGVLGTS STTESSSPQS RQKLSDILLF 1020 HDHCDPILRG GVQQVVGNFL QSSGAGLFLD LQRGLGLQHL LAILLKGFED EIHTVVIQAL 1080 NAFDKIFPNV VSKYLTEPPC HYHAHQQQQQ QQKEQQQQEQ DNQKLEQDLQ RHSSGQQKRS 1140 GQAQTFGQQT FAKDQDNALS SQRQQQRRPN DAGTCANSSA TDNDELLAAL LNDFQLQSTG 1200 MRQQPKNNST DTGQSGNEPD LEPNPNAAVE PFCVFAISPK LLLSKLRLCH HNKYWLVQNK 1260 YAEVISNLNY VLLRSYYANF RCAIDNKNSG ARKQDSKWPP MDASSVCHSV RDAEGEDIVC 1320 TYEAQFLAEL LHLLGDDDAR VREHAACCLC RFIMQTARQD PSQDQGAGGG GGDDIEGNGN 1380 VNVETQQTNF NLLWDFFDYR IFGSMSVTLR NLFRASSTIV PPLAELDALA TSNSAPSYPD 1440 TGSTSGSSTS TSASSGGSAA AVSAASAYFE ASYGIGIAEG HVFALASASQ RQIAQEEKVL 1500 AKVLYRLTNK LMTLNDKNVQ FGIIYALRLL LRHFNFVDYQ QVWLEFNFVE ICISYAYYNN 1560 ATAADLGCQN DLIDVMGKLM AGAMLSSGEP NTAHLDFLLR HSVKMLNIYY HLVTNQRPPT 1620 AGSQSGSSSS KQPKSELFAR EQPAATLQAL GYFAGDYVYM KLYNILRGAN DSYKITINQE 1680 AGSLLICLLK TCLHAVSLCL EGMASASPPE LKLIEEILHY LTRLINYAPA ECVACLRQLL 1740 KYLFAQNYAS QVRLQPSAIG GNGSEIGHHA AFMRPYFAAK GRGHGASSTL LPTINSKPAV 1800 AVGSQRGAPT DARQPIDAGP LQDMGMLFVH GLQPPTPPAG DCVRLIKLFE PMVIYCLTLF 1860 MKSNALVQAP ILRLLSQLLD LNVTYSILDS KNVIFDQVLS NMDLIEGGID RNAFIMVPPM 1920 LRFLVQLTHK SDRQLITIPK IISITNNLLA NGSVRVVALL ALKTLSYELF FMHSQLEEAL 1980 DTEGHNSGRD ACQSPLSAAP TPETREALLA QRRELDTQRE VVLGMLEKFI EARPSQQVLA 2040 LLLLFERSVQ QLDTPPYRSA QDADAVYGTL CRGLCSRQWR LHNAGDLRLL ESCFRNNGNH 2100 VLADSKRFLQ LLQLFIEQGV GNFGDLALAM VMLSNVILKT EEIYLVNHIK LYLKNNPTAE 2160 RRLQALMPSS PSAAPHWQDE APSTSSAAAA ARAAAASFSA GRSSISEINY FAKVLCEKLL 2220 ACLEVLLGLE PSSSSHAYCQ LTGRFMDALL NVCCRSRHKD ALQSVFRLVL AESEFLCKYY 2280 SLLLMSAAGL VGSYLLDAVL LACLRLVLAM RLEEPVALLE QAAQLPLKTN LQRALLREVC 2340 RASAGCDWSA QQVRRLFEGR YLNFLIADHL EFICELCQER PECGSLLQVA LFRNAHRLSR 2400 QSVRIVLRLL GRLCEPAERE ASGDVGSDAD PTLQAMQLLS RLHQLYEGER SLQLPIERMA 2460 RRLSAQSGQP ARNVIYERLV EGDLAGGEDQ DALRTLLLKD LECRQDNETA TPSRIIDESW 2520 LFAQLIKFAT QHADAPQQQK QLMLLLLEIQ SEPKLQRLLR SLGTEHEAKL LRHAIAGSLA 2580 AMMSAFRQKC IQHAPHINYM QPTPLARVSC ALLMSRVAST EATKCRNPPT GEQLDVARAV 2640 GALMACIRNA EQTALIYIDA RLMEKFVVEH LLRREHLPQL LAYLGWLAGA AKQILAMPTR 2700 QESEQDALGV LLATVNTLLQ QPRVWRELNA SSDPSLRCEL LDLLDSVARC ILQDTIFYRR 2760 HRRDRNKAKG PAPQAIFLAK LIETQIEIES LASGRVLAGV EEARLQFAGQ DLARFQVALS 2820 LVTSIGISLL RTHQFYAYAV TPHELIQQPG DQQQEQQADG KLPSIPVDSL SDVDVLRQFV 2880 KRLSIFGFTT RQQFEEYFMT CLLLINKLYD EHMVDQQEQF QIKQVCLQAI LELLMTYKTF 2940 PIVGLANGQF HHTTRWQRIT CDSISLKKLH KVQLLVDACN VFYQPNLERQ LAYDNVIGTR 3000 TFAPNQYDLN FSWAQMEDQA AAGVGVGVGV GLSGGEQANT ADIKQSCDAD VPDMAMRNYR 3060 HFTQLSGIDF RSSTQLVFDV LQQMIELNHI LVLPNLVKFC EICESRDHIK WIKERCLKLQ 3120 EQVAMDDTIS HQHIIYLLCR SQALLIPSLG ELQVLCSLIG NVYLKSTHSF IRIATLQGLL 3180 CLLECCSKTN TTMGRLSEEL ALLRSLIVGY INRHGIIDES PLPFSVEHTK LVWTLNYSLI 3240 EWTSKFVPQC HLLSNTIIAA NNFLKTTADE ELYLCVLHGL ERMVVNSGVP PPGIQPTGKD 3300 AAAGEPGAEG SKAGVGVVVT PQMRHKIEKL ALELLKMENE KFSIPALKLL LSCMYVGSAA 3360 QLENTELSNG IVQDDPEIIA QQNDKVDILL HCIKSSTRDA AWIYGQVLCQ IIRDLVPPNE 3420 ILTKVIKEFL AINHPHCDVI AMIVYQVFRS AIDSSYLQML QDWLICTLPT FLDQPEQQGV 3480 WGLSVIFLSA SINLHLIKLF PLVLGIGASN SAAAATTATT ATTEAEAAAP AMARKLGQHE 3540 IALFVTAAQD FHAKLSGEQR QRFREAFGSF KRSQVYGRML QCL 3584 Fasta Sequence >Q9V3N4\|htt; dHtt; dhtt; DmelCG9995; DmHtt; HD; HsapHD; HTT; Htt; huntingtin; CG9995; Dmel_CG9995\|Drosophila melanogaster (Fruit fly) MDKSRSSAYDKFVGFVEQLRNTECSQKQKITCFQQIAECIMSPSLAGHINYAAHCGTATNVLLLFCEDVDSVVRMSAEENLNKILRSLEKTRVSRILMDLYGEIKRNGNQRSLRICLNLFSYYAPQIKEKHIKWYAVRLLQCMTTISQRKETLLQETLCDFVKHFSRHIQQGLSDSESCKLFETFLDQISSDCAVKRRCSAQNCMSLIENARNRSLMARHGVNKVMELLLTDQQANSVLGALGLLRLLLPQLIRGYPGDSHEDSESLAGKKQQQQQTTTSDCRQIIEIYDYCLHLLSTQHTANHAIINATLEVINGILQAVDAASDGQCSQSLGQSLRQLLCNQQLQHNEYLRRRKSLKNQIFQLKNYEVATSQHQLEDEDENEDVDELVVGATAMQMKKNSNAKLQQAKCREQQQHQHQQQLEVDNSSLGINAGEDAPTEAPSSVADEGGEPESTKLRCHIRNAARSISECVASDEDKQGQGHRQQRDEDGVVVAEDDDDDDDDDDDDDDMELLSAECDDFTTLSQLNEQQQALSAALKLPTTTAASSGGAATSQDDKLIDVDADVGGLPKPQHQSSLQNLLAGSDDKSQHLSDIDNESFNSIDFDAEITIAGSKEQQQQHPPADDSVESGDATAIGTFFNNLLSHSNAASESVSKLFRQSSGSKSTPSKSASTPAPADKSDAISAASLTLSLTSLASSNLEPPERQPLIAETPTPVEDSCSITASHTASTALMMDAPAVEVAASKPETPQLRGTPNANPFLVENSPLRQTVVGRALITVKIGSILEQSLVYYTARLVAARFLLSGQAAGLQPDSISRVSIKSLSLAVIAQCVRLAPKILQLSLEISEQELQLLEEATSQIGSGDSTQVSSPQSSDNSQVGGEKPPLDSSLVPTSLEENLLLLDIKDDHFGPSTCPAYLQSATPTLSRSADASVLLLEGGTTSSRSAKKSEEMLSKSEIIESSYRPTVAVEDVPPLSMPPRPPKRTKSTRSRVGVLGTSSTTESSSPQSRQKLSDILLFHDHCDPILRGGVQQVVGNFLQSSGAGLFLDLQRGLGLQHLLAILLKGFEDEIHTVVIQALNAFDKIFPNVVSKYLTEPPCHYHAHQQQQQQQKEQQQQEQDNQKLEQDLQRHSSGQQKRSGQAQTFGQQTFAKDQDNALSSQRQQQRRPNDAGTCANSSATDNDELLAALLNDFQLQSTGMRQQPKNNSTDTGQSGNEPDLEPNPNAAVEPFCVFAISPKLLLSKLRLCHHNKYWLVQNKYAEVISNLNYVLLRSYYANFRCAIDNKNSGARKQDSKWPPMDASSVCHSVRDAEGEDIVCTYEAQFLAELLHLLGDDDARVREHAACCLCRFIMQTARQDPSQDQGAGGGGGDDIEGNGNVNVETQQTNFNLLWDFFDYRIFGSMSVTLRNLFRASSTIVPPLAELDALATSNSAPSYPDTGSTSGSSTSTSASSGGSAAAVSAASAYFEASYGIGIAEGHVFALASASQRQIAQEEKVLAKVLYRLTNKLMTLNDKNVQFGIIYALRLLLRHFNFVDYQQVWLEFNFVEICISYAYYNNATAADLGCQNDLIDVMGKLMAGAMLSSGEPNTAHLDFLLRHSVKMLNIYYHLVTNQRPPTAGSQSGSSSSKQPKSELFAREQPAATLQALGYFAGDYVYMKLYNILRGANDSYKITINQEAGSLLICLLKTCLHAVSLCLEGMASASPPELKLIEEILHYLTRLINYAPAECVACLRQLLKYLFAQNYASQVRLQPSAIGGNGSEIGHHAAFMRPYFAAKGRGHGASSTLLPTINSKPAVAVGSQRGAPTDARQPIDAGPLQDMGMLFVHGLQPPTPPAGDCVRLIKLFEPMVIYCLTLFMKSNALVQAPILRLLSQLLDLNVTYSILDSKNVIFDQVLSNMDLIEGGIDRNAFIMVPPMLRFLVQLTHKSDRQLITIPKIISITNNLLANGSVRVVALLALKTLSYELFFMHSQLEEALDTEGHNSGRDACQSPLSAAPTPETREALLAQRRELDTQREVVLGMLEKFIEARPSQQVLALLLLFERSVQQLDTPPYRSAQDADAVYGTLCRGLCSRQWRLHNAGDLRLLESCFRNNGNHVLADSKRFLQLLQLFIEQGVGNFGDLALAMVMLSNVILKTEEIYLVNHIKLYLKNNPTAERRLQALMPSSPSAAPHWQDEAPSTSSAAAAARAAAASFSAGRSSISEINYFAKVLCEKLLACLEVLLGLEPSSSSHAYCQLTGRFMDALLNVCCRSRHKDALQSVFRLVLAESEFLCKYYSLLLMSAAGLVGSYLLDAVLLACLRLVLAMRLEEPVALLEQAAQLPLKTNLQRALLREVCRASAGCDWSAQQVRRLFEGRYLNFLIADHLEFICELCQERPECGSLLQVALFRNAHRLSRQSVRIVLRLLGRLCEPAEREASGDVGSDADPTLQAMQLLSRLHQLYEGERSLQLPIERMARRLSAQSGQPARNVIYERLVEGDLAGGEDQDALRTLLLKDLECRQDNETATPSRIIDESWLFAQLIKFATQHADAPQQQKQLMLLLLEIQSEPKLQRLLRSLGTEHEAKLLRHAIAGSLAAMMSAFRQKCIQHAPHINYMQPTPLARVSCALLMSRVASTEATKCRNPPTGEQLDVARAVGALMACIRNAEQTALIYIDARLMEKFVVEHLLRREHLPQLLAYLGWLAGAAKQILAMPTRQESEQDALGVLLATVNTLLQQPRVWRELNASSDPSLRCELLDLLDSVARCILQDTIFYRRHRRDRNKAKGPAPQAIFLAKLIETQIEIESLASGRVLAGVEEARLQFAGQDLARFQVALSLVTSIGISLLRTHQFYAYAVTPHELIQQPGDQQQEQQADGKLPSIPVDSLSDVDVLRQFVKRLSIFGFTTRQQFEEYFMTCLLLINKLYDEHMVDQQEQFQIKQVCLQAILELLMTYKTFPIVGLANGQFHHTTRWQRITCDSISLKKLHKVQLLVDACNVFYQPNLERQLAYDNVIGTRTFAPNQYDLNFSWAQMEDQAAAGVGVGVGVGLSGGEQANTADIKQSCDADVPDMAMRNYRHFTQLSGIDFRSSTQLVFDVLQQMIELNHILVLPNLVKFCEICESRDHIKWIKERCLKLQEQVAMDDTISHQHIIYLLCRSQALLIPSLGELQVLCSLIGNVYLKSTHSFIRIATLQGLLCLLECCSKTNTTMGRLSEELALLRSLIVGYINRHGIIDESPLPFSVEHTKLVWTLNYSLIEWTSKFVPQCHLLSNTIIAANNFLKTTADEELYLCVLHGLERMVVNSGVPPPGIQPTGKDAAAGEPGAEGSKAGVGVVVTPQMRHKIEKLALELLKMENEKFSIPALKLLLSCMYVGSAAQLENTELSNGIVQDDPEIIAQQNDKVDILLHCIKSSTRDAAWIYGQVLCQIIRDLVPPNEILTKVIKEFLAINHPHCDVIAMIVYQVFRSAIDSSYLQMLQDWLICTLPTFLDQPEQQGVWGLSVIFLSASINLHLIKLFPLVLGIGASNSAAAATTATTATTEAEAAAPAMARKLGQHEIALFVTAAQDFHAKLSGEQRQRFREAFGSFKRSQVYGRMLQCL

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	SUMOylation	Huntington's disease		P		23871671
1	[Reference]: Finally, the accumulation of SUMO-2-modified proteins in the insoluble fraction of HD postmortem striata implicates SUMO-2?modification?in the age-related pathogenic accumulation of mutant HTT and other cellular proteins that occurs during HD progression.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 4)	MESH:D002105 ; Cadmium Poisoning MESH:D006816 ; Huntington Disease MESH:D020149 ; Manganese Poisoning MESH:D009069 ; Movement Disorders

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	1140 SSGQQKRSGQAQTFG dbPAF 1447 DTGSTSGSSTSTSAS dbPAF 2170 LQALMPSSPSAAPHW dbPAF 266 DSHEDSESLAGKKQQ dbPAF 3197 NTTMGRLSEELALLR dbPAF 470 RNAARSISECVASDE dbPAF 475 SISECVASDEDKQGQ dbPAF 578 PKPQHQSSLQNLLAG dbPAF 930 ATPTLSRSADASVLL dbPAF 951 SSRSAKKSEEMLSKS dbPAF

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P15330	Q9V3N4	IntAct
Q7KLE5	Q9V3N4	IntAct