Q9UQM7

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession KCC2A_HUMAN; Q9UQM7;
Entrez ID 815
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene Name CAMK2A; CAMKA; KIAA0968
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence
(Fasta)		MATITCTRFT EEYQLFEELG KGAFSVVRRC VKVLAGQEYA AKIINTKKLS ARDHQKLERE 60
ARICRLLKHP NIVRLHDSIS EEGHHYLIFD LVTGGELFED IVAREYYSEA DASHCIQQIL 120
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVEGEQQAW FGFAGTPGYL 180
SPEVLRKDPY GKPVDLWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 240
TPEAKDLINK MLTINPSKRI TAAEALKHPW ISHRSTVASC MHRQETVDCL KKFNARRKLK 300
GAILTTMLAT RNFSGGKSGG NKKSDGVKES SESTNTTIED EDTKVRKQEI IKVTEQLIEA 360
ISNGDFESYT KMCDPGMTAF EPEALGNLVE GLDFHRFYFE NLWSRNSKPV HTTILNPHIH 420
LMGDESACIA YIRITQYLDA GGIPRTAQSE ETRVWHRRDG KWQIVHFHRS GAPSVLPH 479

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationBreast cancer/tumor/carcinomaCell LinesUT28627605043
[Reference]: We demonstrate herein that CaMKII expression and phosphorylation at T286 is increased in breast cancer when compared to normal breast tissue, and that increased CAMK2 mRNA is associated with poor breast cancer patient prognosis

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D019970 ; Cocaine-Related Disorders
MESH:D006527 ; Hepatolenticular Degeneration
MESH:D006529 ; Hepatomegaly
MESH:D006930 ; Hyperalgesia
GWASdb
(count: 9)
(view all)		rs3822607; Premature ovarian failure; premature ovarian failure
rs10066581; Urinary metabolites; kidney disease
rs4958456; Obesity-related traits; obesity
rs3756578; Premature ovarian failure; premature ovarian failure
rs869191; Drug response to Etoposide; Null
rs3756577; Smoking quantity; nicotine dependence

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 18)
(view all)		 10        TITCTRFTEEYQLFE     dbPAF
13        CTRFTEEYQLFEELG     dbPAF
234       AGAYDFPSPEWDTVT     dbPAF
253       DLINKMLTINPSKRI     dbPAF
275       HPWISHRSTVASCMH     dbPAF
286       SCMHRQETVDCLKKF     dbPAF
Methylation
(count: 2)		 258       MLTINPSKRITAAEA     PLMD
300       FNARRKLKGAILTTM     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource