Q9UQL6

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	HDAC5_HUMAN; Q9UQL6;
Entrez ID	10014
GenBank Protein ID	NM_001015053.1; NM_005474.4; XM_005256906.4;
GenBank Nucleotide ID	NP_001015053.1; NP_005465.2; XP_005256963.1;
Protein Name	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene Name	HDAC5; KIAA0600
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Functional Description Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Sequence (Fasta)	MNSPNESDGM SGREPSLEIL PRTSLHSIPV TVEVKPVLPR AMPSSMGGGG GGSPSPVELR 60 GALVGSVDPT LREQQLQQEL LALKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 120 QEMLAAKQQQ EMLAAKRQQE LEQQRQREQQ RQEELEKQRL EQQLLILRNK EKSKESAIAS 180 TEVKLRLQEF LLSKSKEPTP GGLNHSLPQH PKCWGAHHAS LDQSSPPQSG PPGTPPSYKL 240 PLPGPYDSRD DFPLRKTASE PNLKVRSRLK QKVAERRSSP LLRRKDGTVI STFKKRAVEI 300 TGAGPGASSV CNSAPGSGPS SPNSSHSTIA ENGFTGSVPN IPTEMLPQHR ALPLDSSPNQ 360 FSLYTSPSLP NISLGLQATV TVTNSHLTAS PKLSTQQEAE RQALQSLRQG GTLTGKFMST 420 SSIPGCLLGV ALEGDGSPHG HASLLQHVLL LEQARQQSTL IAVPLHGQSP LVTGERVATS 480 MRTVGKLPRH RPLSRTQSSP LPQSPQALQQ LVMQQQHQQF LEKQKQQQLQ LGKILTKTGE 540 LPRQPTTHPE ETEEELTEQQ EVLLGEGALT MPREGSTESE STQEDLEEED EEDDGEEEED 600 CIQVKDEEGE SGAEEGPDLE EPGAGYKKLF SDAQPLQPLQ VYQAPLSLAT VPHQALGRTQ 660 SSPAAPGGMK SPPDQPVKHL FTTGVVYDTF MLKHQCMCGN THVHPEHAGR IQSIWSRLQE 720 TGLLSKCERI RGRKATLDEI QTVHSEYHTL LYGTSPLNRQ KLDSKKLLGP ISQKMYAVLP 780 CGGIGVDSDT VWNEMHSSSA VRMAVGCLLE LAFKVAAGEL KNGFAIIRPP GHHAEESTAM 840 GFCFFNSVAI TAKLLQQKLN VGKVLIVDWD IHHGNGTQQA FYNDPSVLYI SLHRYDNGNF 900 FPGSGAPEEV GGGPGVGYNV NVAWTGGVDP PIGDVEYLTA FRTVVMPIAH EFSPDVVLVS 960 AGFDAVEGHL SPLGGYSVTA RCFGHLTRQL MTLAGGRVVL ALEGGHDLTA ICDASEACVS 1020 ALLSVELQPL DEAVLQQKPN INAVATLEKV IEIQSKHWSC VQKFAAGLGR SLREAQAGET 1080 EEAETVSAMA LLSVGAEQAQ AAAAREHSPR PAEEPMEQEP AL 1123 Fasta Sequence >Q9UQL6\|HDAC5; KIAA0600\|Homo sapiens (Human) MNSPNESDGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Heart failure		U	S279	20716686
1	[Reference]: PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 3)	MESH:D000275 ; Adjustment Disorders MESH:D019970 ; Cocaine-Related Disorders MESH:D065627 ; Familial Primary Pulmonary Hypertension
DisGeNet (Curated) (count: 7) (view all)	C0001546; Adjustment Disorders C0011570; Mental Depression C0011581; Depressive disorder C0041696; Unipolar Depression C0236736; Cocaine-Related Disorders C0340543; Familial primary pulmonary hypertension C1269683; Major Depressive Disorder
GWASdb (count: 5)	rs228768; Multiple complex diseases; Null rs228769; Bone mineral density (hip); bone resorption disease rs228769; Bone mineral density (spine); bone resorption disease rs453789; Triglycerides; coronary artery disease\|lipid metabolism disorder\|arteriosclerosis rs79605584; Cocaine dependence; cocaine dependence

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 34) (view all)	1071 FAAGLGRSLREAQAG dbPAF 1108 AAAAREHSPRPAEEP dbPAF 180 SKESAIASTEVKLRL dbPAF 181 KESAIASTEVKLRLQ dbPAF 206 TPGGLNHSLPQHPKC dbPAF 234 PQSGPPGTPPSYKLP dbPAF 259 FPLRKTASEPNLKVR dbPAF 278 QKVAERRSSPLLRRK dbPAF 279 KVAERRSSPLLRRKD dbPAF 288 LLRRKDGTVISTFKK dbPAF 291 RKDGTVISTFKKRAV dbPAF 292 KDGTVISTFKKRAVE dbPAF 3 ****MNSPNESDGM dbPAF 368 FSLYTSPSLPNISLG dbPAF 469 AVPLHGQSPLVTGER dbPAF 496 RHRPLSRTQSSPLPQ dbPAF 498 RPLSRTQSSPLPQSP dbPAF 499 PLSRTQSSPLPQSPQ dbPAF 504 QSSPLPQSPQALQQL dbPAF 53 MGGGGGGSPSPVELR dbPAF 546 GELPRQPTTHPEETE dbPAF 547 ELPRQPTTHPEETEE dbPAF 55 GGGGGSPSPVELRGA dbPAF 611 VKDEEGESGAEEGPD dbPAF 659 PHQALGRTQSSPAAP dbPAF 66 LRGALVGSVDPTLRE dbPAF 661 QALGRTQSSPAAPGG dbPAF 671 AAPGGMKSPPDQPVK dbPAF 7 MNSPNESDGMSGRE dbPAF 70 LVGSVDPTLREQQLQ dbPAF 755 HTLLYGTSPLNRQKL dbPAF 776 GPISQKMYAVLPCGG dbPAF 798 VWNEMHSSSAVRMAV dbPAF 799 WNEMHSSSAVRMAVG dbPAF
Acetylation (count: 1)	533 QQQLQLGKILTKTGE PLMD
Sumoylation (count: 2)	35 IPVTVEVKPVLPRAM PLMD 533 QQQLQLGKILTKTGE PLMD
Glycation (count: 2)	194 LQEFLLSKSKEPTPG PLMD 196 EFLLSKSKEPTPGGL PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

O43463	Q9UQL6	HPRD
O75376	Q9UQL6	HPRD
P31947	Q9UQL6	HPRD
P62805	Q9UQL6	IntAct