Q9UQ07

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession MOK_HUMAN; Q9UQ07;
Entrez ID 5891
GenBank Protein ID NM_001272011.1; NM_001330234.1; NM_014226.2;
GenBank Nucleotide ID NP_001258940.1; NP_001317163.1; NP_055041.1;
Protein Name MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1)
Gene Name MOK; RAGE; RAGE1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionAble to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Sequence
(Fasta)		MKNYKAIGKI GEGTFSEVMK MQSLRDGNYY ACKQMKQRFE SIEQVNNLRE IQALRRLNPH 60
PNILMLHEVV FDRKSGSLAL ICELMDMNIY ELIRGRRYPL SEKKIMHYMY QLCKSLDHIH 120
RNGIFHRDVK PENILIKQDV LKLGDFGSCR SVYSKQPYTE YISTRWYRAP ECLLTDGFYT 180
YKMDLWSAGC VFYEIASLQP LFPGVNELDQ ISKIHDVIGT PAQKILTKFK QSRAMNFDFP 240
FKKGSGIPLL TTNLSPQCLS LLHAMVAYDP DERIAAHQAL QHPYFQEQRK TEKRALGSHR 300
KAGFPEHPVA PEPLSNSCQI SKEGRKQKQS LKQEEDRPKR RGPAYVMELP KLKLSGVVRL 360
SSYSSPTLQS VLGSGTNGRV PVLRPLKCIP ASKKTDPQKD LKPAPQQCRL PTIVRKGGR 420

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1GlycosylationLung cancer/carcinomacell lineP23874853; 3708913
[Reference]: Our findings demonstrated a potential interactive contribution of RAGE and APE1 genes to the pathogenesis of lung cancer among Han Chinese. Further studies are warranted to confirm or refute these findings.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D003924 ; Diabetes Mellitus, Type 2
HGMD
(count: 3)		CI072603; Protein kinase deficiency; Small insertions
CM071967; Protein kinase deficiency; Missense/nonsense
CM071966; Protein kinase deficiency; Missense/nonsense
GWASdb
(count: 1)		rs7148939; Urinary metabolites; kidney disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)		 159       VYSKQPYTEYISTRW     dbPAF
161       SKQPYTEYISTRWYR     dbPAF
220       KIHDVIGTPAQKILT     dbPAF
29        QSLRDGNYYACKQMK     dbPAF
298       TEKRALGSHRKAGFP     dbPAF
330       EGRKQKQSLKQEEDR     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource