Q9UN36

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession NDRG2_HUMAN; Q9UN36;
Entrez ID 57447
GenBank Protein ID NM_001282211.1; NM_001282212.1; NM_001282213.1; NM_001282214.1; NM_001282215.1; NM_001282216.1; NM_001320329.1; NM_016250.2; NM_201535.1; NM_201536.1; NM_201537.1; NM_201538.1; NM_201539.1; NM_201540.1; NM_201541.1; XM_011536996.2; XM_011536997.1; XM_011536998.1; XM_011536999.1; XM_011537001.1; XM_011537002.1;
GenBank Nucleotide ID NP_001269140.1; NP_001269141.1; NP_001269142.1; NP_001269143.1; NP_001269144.1; NP_001269145.1; NP_001307258.1; NP_057334.1; NP_963293.1; NP_963294.1; NP_963831.1; NP_963832.1; NP_963833.1; NP_963834.1; NP_963835.1; XP_011535298.1; XP_011535299.1; XP_011535300.1; XP_011535301.1; XP_011535303.1; XP_011535304.1;
Protein Name Protein NDRG2 (N-myc downstream-regulated gene 2 protein) (Protein Syld709613) [Cleaved into: Protein NDRG2, N-terminally processed]
Gene Name NDRG2; KIAA1248; SYLD
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionContributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
Sequence
(Fasta)		MAELQEVQIT EEKPLLPGQT PEAAKEAELA ARILLDQGQT HSVETPYGSV TFTVYGTPKP 60
KRPAILTYHD VGLNYKSCFQ PLFQFEDMQE IIQNFVRVHV DAPGMEEGAP VFPLGYQYPS 120
LDQLADMIPC VLQYLNFSTI IGVGVGAGAY ILARYALNHP DTVEGLVLIN IDPNAKGWMD 180
WAAHKLTGLT SSIPEMILGH LFSQEELSGN SELIQKYRNI ITHAPNLDNI ELYWNSYNNR 240
RDLNFERGGD ITLRCPVMLV VGDQAPHEDA VVECNSKLDP TQTSFLKMAD SGGQPQLTQP 300
GKLTEAFKYF LQGMGYMASS CMTRLSRSRT ASLTSAASVD GNRSRSRTLS QSSESGTLSS 360
GPPGHTMEVS C 372

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationGastric cancerMKN28 cell linPS33223558861
[Reference]: Further investigation demonstrated that the relative phosphorylation levels of Ndrg2 at Ser332, Thr348 increased up to 3.2- and 1.9-fold (hyperthermia group vs control group) at 3 h in MKN28 cells, respectively (P < 0.05).
2Threonine PhosphorylationGastric cancerMKN28 cell linPT34823558861
[Reference]: Further investigation demonstrated that the relative phosphorylation levels of Ndrg2 at Ser332, Thr348 increased up to 3.2- and 1.9-fold (hyperthermia group vs control group) at 3 h in MKN28 cells, respectively (P < 0.05).

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D002386 ; Cataract
MESH:D003110 ; Colonic Neoplasms
MESH:D002546 ; Ischemic Attack, Transient
MESH:D008106 ; Liver Cirrhosis, Experimental
GWASdb
(count: 1)		rs4981349; Obesity-related traits; obesity

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 27)
(view all)		 20        KPLLPGQTPEAAKEA     dbPAF
276       DAVVECNSKLDPTQT     dbPAF
319       QGMGYMASSCMTRLS     dbPAF
323       YMASSCMTRLSRSRT     dbPAF
326       SSCMTRLSRSRTASL     dbPAF
328       CMTRLSRSRTASLTS     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource