Tag | Content |
---|---|
UniProt Accession | SYNP2_HUMAN; Q9UMS6; |
Entrez ID | 171024 |
GenBank Protein ID | NM_001128933.2; NM_001128934.2; NM_001286754.1; NM_133477.2; |
GenBank Nucleotide ID | NP_001122405.1; NP_001122406.1; NP_001273683.1; NP_597734.2; |
Protein Name | Synaptopodin-2 (Genethonin-2) (Myopodin) |
Gene Name | SYNPO2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner (PubMed:24005909, PubMed:23225103). At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client(view all) |
Sequence (Fasta) | MGTGDFICIS MTGGAPWGFR LQGGKEQKQP LQVAKIRNQS KASGSGLCEG DEVVSINGNP 60 CADLTYPEVI KLMESITDSL QMLIKRPSSG ISEALISENE NKNLEHLTHG GYVESTTLQI 120 RPATKTQCTE FFLAPVKTEV PLAENQRSGP DCAGSLKEET GPSYQRAPQM PDSQRGRVAE 180 ELILREKVEA VQPGPVVELQ LSLSQERHKG ASGPLVALPG AEKSKSPDPD PNLSHDRIVH 240 INSIPTNEKA DPFLRSSKII QISSGRELRV IQESEAGDAG LPRVEVILDC SDRQKTEGCR 300 LQAGKECVDS PVEGGQSEAP PSLVSFAVSS EGTEQGEDPR SEKDHSRPHK HRARHARLRR 360 SESLSEKQVK EAKSKCKSIA LLLTDAPNPN SKGVLMFKKR RRRARKYTLV SYGTGELERE 420 ADEEEEGDKE DTCEVAFLGA SESEVDEELL SDVDDNTQVV NFDWDSGLVD IEKKLNRGDK 480 MEMLPDTTGK GALMFAKRRE RMDQITAQKE EDKVGGTPSR EQDAAQTDGL RTTTSYQRKE 540 EESVRTQSSV SKSYIEVSHG LGHVPQQNGF SGTSETANIQ RMVPMNRTAK PFPGSVNQPA 600 TPFSPTRNMT SPIADFPAPP PYSAVTPPPD AFSRGVSSPI AGPAQPPPWP QPAPWSQPAF 660 YDSSERIASR DERISVPAKR TGILQEAKRR STTKPMFTFK EPKVSPNPEL LSLLQNSEGK 720 RGTGAGGDSG PEEDYLSLGA EACNFMQSSS AKQKTPPPVA PKPAVKSSSS QPVTPVSPVW 780 SPGVAPTQPP AFPTSNPSKG TVVSSIKIAQ PSYPPARPAS TLNVAGPFKG PQAAVASQNY 840 TPKPTVSTPT VNAVQPGAVG PSNELPGMSG RGAQLFAKRQ SRMEKYVVDS DTVQAHAARA 900 QSPTPSLPAS WKYSSNVRAP PPVAYNPIHS PSYPLAALKS QPSAAQPSKM GKKKGKKPLN 960 ALDVMKHQPY QLNASLFTFQ PPDAKDGLPQ KSSVKVNSAL AMKQALPPRP VNAASPTNVQ 1020 ASSVYSVPAY TSPPSFFAEA SSPVSASPVP VGIPTSPKQE SASSSYFVAP RPKFSAKKSG 1080 VTIQVWKPSV VEE 1094 |
|
Database | Annotation |
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CTD (Curated) (count: 1) | MESH:C538090 ; Ovarian epithelial cancer |
DisGeNet (Curated) (count: 1) | C0677886; Epithelial ovarian cancer |
GWASdb (count: 14) (view all) | rs13117019; Smoking cessation; nicotine dependence
rs10518319; Smoking cessation; nicotine dependence rs1472066; IgE levels in asthmatics; asthma rs4834729; Alcohol dependence; alcohol dependence rs4261974; Transmission distortion; Null rs1038770; IgE levels in asthmatics; asthma |
PTM | Modification Sites |
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Phosphorylation (count: 56) (view all) | 1041 PSFFAEASSPVSASP dbPAF
1042 SFFAEASSPVSASPV dbPAF 1047 ASSPVSASPVPVGIP dbPAF 1055 PVPVGIPTSPKQESA dbPAF 1056 VPVGIPTSPKQESAS dbPAF 1066 QESASSSYFVAPRPK dbPAF |
Ubiquitination (count: 1) | 688 TGILQEAKRRSTTKP PLMD |
Glycation (count: 2) | 480 KKLNRGDKMEMLPDT PLMD
497 KGALMFAKRRERMDQ PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |