Q9UM73

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ALK_HUMAN; Q9UM73;
Entrez ID 238
GenBank Protein ID
GenBank Nucleotide ID
Protein Name ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246)
Gene Name ALK
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionNeuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, a(view all)
Sequence
(Fasta)
MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 60
PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 120
RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 180
GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 240
FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 300
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 360
YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 420
ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 480
NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 540
APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 600
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 660
NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 720
KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 780
DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 840
AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 900
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 960
PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 1020
CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 1080
SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 1140
DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 1200
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 1260
GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 1320
EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 1380
ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 1440
PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 1500
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 1560
SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP 1620
1621

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomacell linePY150722570254
[Reference]: This phospho site was also observed in primary tumor tissues and cell lines of NSCLC bearing EML-ALK fusions, as well as neuroblastoma cell lines bearing ALK-activating mutations
2Tyrosine PhosphorylationNon-small cell lung cancer/carcinomacell linePY150722570254
[Reference]: This phospho site was also observed in primary tumor tissues and cell lines of NSCLC bearing EML-ALK fusions, as well as neuroblastoma cell lines bearing ALK-activating mutations
3Tyrosine PhosphorylationOvarian cancer/carcinomaPY150722570254
[Reference]: Using an unbiased and global phosphoproteomic approach, we profiled 69 Chinese primary ovarian tumor tissues and found ALK to be aberrantly expressed and phosphorylated in 4 tumors

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
ALCL, NSCLC, neuroblastoma, inflammatory myofibroblastic tumour, Spitzoid tumour neuroblastoma familial neuroblastoma
CTD (Curated)
(count: 13)
(view all)
MESH:C538231 ; Adenocarcinoma of lung
MESH:D001932 ; Brain Neoplasms
MESH:D002292 ; Carcinoma, Renal Cell
MESH:D002471 ; Cell Transformation, Neoplastic
MESH:D006104 ; Granuloma, Plasma Cell
MESH:D058922 ; Inflammatory Breast Neoplasms
DisGeNet (Curated)
(count: 25)
(view all)
C0001973; Alcoholic Intoxication, Chronic
C0006118; Brain Neoplasms
C0007131; Non-Small Cell Lung Carcinoma
C0007134; Renal Cell Carcinoma
C0007621; Neoplastic Cell Transformation
C0011570; Mental Depression
HGMD
(count: 5)
CM084938; Neuroblastoma; Missense/nonsense
CM085232; Neuroblastoma; Missense/nonsense
CM085229; Neuroblastoma; Missense/nonsense
CM085231; Neuroblastoma; Missense/nonsense
CM085230; Neuroblastoma; Missense/nonsense
GWASdb
(count: 110)
(view all)
rs4622670; Amyotrophic lateral sclerosis; amyotrophic lateral sclerosis
rs7572088; Serum metabolites; Null
rs2339379; Serum metabolites; Null
rs17007760; Alzheimer's disease; Alzheimer's disease
rs12617579; Nicotine smoking; nicotine dependence
rs35228363; Prostate cancer; prostate cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 34)
(view all)
1075      AMQMELQSPEYKLSK     dbPAF
1078      MELQSPEYKLSKLRT     dbPAF
1081      QSPEYKLSKLRTSTI     dbPAF
1090      LRTSTIMTDYNPNYC     dbPAF
1092      TSTIMTDYNPNYCFA     dbPAF
1096      MTDYNPNYCFAGKTS     dbPAF
Ubiquitination
(count: 4)
1498      KVHGSRNKPTSLWNP     PLMD
1514      YGSWFTEKPTKKNNP     PLMD
1517      WFTEKPTKKNNPIAK     PLMD
831       ATYVFKMKDGVPVPL     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource