Tag | Content |
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UniProt Accession | ALK_HUMAN; Q9UM73; |
Entrez ID | 238 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | ALK tyrosine kinase receptor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD antigen CD246) |
Gene Name | ALK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, a(view all) |
Sequence (Fasta) | MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 60 PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 120 RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 180 GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 240 FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 300 MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 360 YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 420 ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 480 NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 540 APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 600 LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 660 NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 720 KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 780 DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 840 AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 900 TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 960 PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 1020 CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 1080 SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 1140 DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 1200 GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 1260 GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 1320 EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 1380 ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 1440 PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 1500 SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 1560 SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP 1620 1621 |
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Database | Annotation |
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Cancer Gene Census | ALCL, NSCLC, neuroblastoma, inflammatory myofibroblastic tumour, Spitzoid tumour neuroblastoma familial neuroblastoma |
CTD (Curated) (count: 13) (view all) | MESH:C538231
; Adenocarcinoma of lung MESH:D001932 ; Brain Neoplasms MESH:D002292 ; Carcinoma, Renal Cell MESH:D002471 ; Cell Transformation, Neoplastic MESH:D006104 ; Granuloma, Plasma Cell MESH:D058922 ; Inflammatory Breast Neoplasms |
DisGeNet (Curated) (count: 25) (view all) | C0001973; Alcoholic Intoxication, Chronic
C0006118; Brain Neoplasms C0007131; Non-Small Cell Lung Carcinoma C0007134; Renal Cell Carcinoma C0007621; Neoplastic Cell Transformation C0011570; Mental Depression |
HGMD (count: 5) | CM084938; Neuroblastoma; Missense/nonsense
CM085232; Neuroblastoma; Missense/nonsense CM085229; Neuroblastoma; Missense/nonsense CM085231; Neuroblastoma; Missense/nonsense CM085230; Neuroblastoma; Missense/nonsense |
GWASdb (count: 110) (view all) | rs4622670; Amyotrophic lateral sclerosis; amyotrophic lateral sclerosis
rs7572088; Serum metabolites; Null rs2339379; Serum metabolites; Null rs17007760; Alzheimer's disease; Alzheimer's disease rs12617579; Nicotine smoking; nicotine dependence rs35228363; Prostate cancer; prostate cancer |
PTM | Modification Sites |
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Phosphorylation (count: 34) (view all) | 1075 AMQMELQSPEYKLSK dbPAF
1078 MELQSPEYKLSKLRT dbPAF 1081 QSPEYKLSKLRTSTI dbPAF 1090 LRTSTIMTDYNPNYC dbPAF 1092 TSTIMTDYNPNYCFA dbPAF 1096 MTDYNPNYCFAGKTS dbPAF |
Ubiquitination (count: 4) | 1498 KVHGSRNKPTSLWNP PLMD
1514 YGSWFTEKPTKKNNP PLMD 1517 WFTEKPTKKNNPIAK PLMD 831 ATYVFKMKDGVPVPL PLMD |
Network | Interaction | ||
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A | B | Source | |