Q9UKV8

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession AGO2_HUMAN; Q9UKV8;
Entrez ID 27161
GenBank Protein ID NM_001164623.2; NM_012154.4;
GenBank Nucleotide ID NP_001158095.1; NP_036286.2;
Protein Name Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Gene Name AGO2; EIF2C2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRequired for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleol(view all)
Sequence
(Fasta)
MYSGAGPALA PPAPPPPIQG YAFKPPPRPD FGTSGRTIKL QANFFEMDIP KIDIYHYELD 60
IKPEKCPRRV NREIVEHMVQ HFKTQIFGDR KPVFDGRKNL YTAMPLPIGR DKVELEVTLP 120
GEGKDRIFKV SIKWVSCVSL QALHDALSGR LPSVPFETIQ ALDVVMRHLP SMRYTPVGRS 180
FFTASEGCSN PLGGGREVWF GFHQSVRPSL WKMMLNIDVS ATAFYKAQPV IEFVCEVLDF 240
KSIEEQQKPL TDSQRVKFTK EIKGLKVEIT HCGQMKRKYR VCNVTRRPAS HQTFPLQQES 300
GQTVECTVAQ YFKDRHKLVL RYPHLPCLQV GQEQKHTYLP LEVCNIVAGQ RCIKKLTDNQ 360
TSTMIRATAR SAPDRQEEIS KLMRSASFNT DPYVREFGIM VKDEMTDVTG RVLQPPSILY 420
GGRNKAIATP VQGVWDMRNK QFHTGIEIKV WAIACFAPQR QCTEVHLKSF TEQLRKISRD 480
AGMPIQGQPC FCKYAQGADS VEPMFRHLKN TYAGLQLVVV ILPGKTPVYA EVKRVGDTVL 540
GMATQCVQMK NVQRTTPQTL SNLCLKINVK LGGVNNILLP QGRPPVFQQP VIFLGADVTH 600
PPAGDGKKPS IAAVVGSMDA HPNRYCATVR VQQHRQEIIQ DLAAMVRELL IQFYKSTRFK 660
PTRIIFYRDG VSEGQFQQVL HHELLAIREA CIKLEKDYQP GITFIVVQKR HHTRLFCTDK 720
NERVGKSGNI PAGTTVDTKI THPTEFDFYL CSHAGIQGTS RPSHYHVLWD DNRFSSDELQ 780
ILTYQLCHTY VRCTRSVSIP APAYYAHLVA FRARYHLVDK EHDSAEGSHT SGQSNGRDHQ 840
ALAKAVQVHQ DTLRTMYFA

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationBreast cancer/tumor/carcinomaUY39323636329
[Reference]: Furthermore, AGO2-Y393 phosphorylation mediates EGFR-enhanced cell survival and invasiveness under hypoxia, and correlates with poorer overall survival in breast cancer patients.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 3)
MESH:D019970 ; Cocaine-Related Disorders
MESH:D007951 ; Leukemia, Myeloid
MESH:C562839 ; Mesothelioma, Malignant
DisGeNet (Curated)
(count: 4)
C0001973; Alcoholic Intoxication, Chronic
C0023470; Myeloid Leukemia
C0236736; Cocaine-Related Disorders
C0345967; Malignant mesothelioma

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 20)
(view all)
153       ALSGRLPSVPFETIQ     dbPAF
251       EEQQKPLTDSQRVKF     dbPAF
253       QQKPLTDSQRVKFTK     dbPAF
303       LQQESGQTVECTVAQ     dbPAF
307       SGQTVECTVAQYFKD     dbPAF
385       EISKLMRSASFNTDP     dbPAF
Acetylation
(count: 4)
276       ITHCGQMKRKYRVCN     PLMD
313       CTVAQYFKDRHKLVL     PLMD
62        YHYELDIKPEKCPRR     PLMD
720       TRLFCTDKNERVGKS     PLMD
Ubiquitination
(count: 9)
(view all)
248       KSIEEQQKPLTDSQR     PLMD
381       DRQEEISKLMRSASF     PLMD
425       ILYGGRNKAIATPVQ     PLMD
533       TPVYAEVKRVGDTVL     PLMD
550       ATQCVQMKNVQRTTP     PLMD
696       EACIKLEKDYQPGIT     PLMD
Sumoylation
(count: 1)
402       REFGIMVKDEMTDVT     PLMD
Glycation
(count: 7)
(view all)
266       TKEIKGLKVEITHCG     PLMD
355       AGQRCIKKLTDNQTS     PLMD
381       DRQEEISKLMRSASF     PLMD
440       GVWDMRNKQFHTGIE     PLMD
608       PPAGDGKKPSIAAVV     PLMD
693       AIREACIKLEKDYQP     PLMD
Malonylation
(count: 2)
608       PPAGDGKKPSIAAVV     PLMD
726       DKNERVGKSGNIPAG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource