Tag | Content |
---|---|
UniProt Accession | AGO2_HUMAN; Q9UKV8; |
Entrez ID | 27161 |
GenBank Protein ID | NM_001164623.2; NM_012154.4; |
GenBank Nucleotide ID | NP_001158095.1; NP_036286.2; |
Protein Name | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) |
Gene Name | AGO2; EIF2C2 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleol(view all) |
Sequence (Fasta) | MYSGAGPALA PPAPPPPIQG YAFKPPPRPD FGTSGRTIKL QANFFEMDIP KIDIYHYELD 60 IKPEKCPRRV NREIVEHMVQ HFKTQIFGDR KPVFDGRKNL YTAMPLPIGR DKVELEVTLP 120 GEGKDRIFKV SIKWVSCVSL QALHDALSGR LPSVPFETIQ ALDVVMRHLP SMRYTPVGRS 180 FFTASEGCSN PLGGGREVWF GFHQSVRPSL WKMMLNIDVS ATAFYKAQPV IEFVCEVLDF 240 KSIEEQQKPL TDSQRVKFTK EIKGLKVEIT HCGQMKRKYR VCNVTRRPAS HQTFPLQQES 300 GQTVECTVAQ YFKDRHKLVL RYPHLPCLQV GQEQKHTYLP LEVCNIVAGQ RCIKKLTDNQ 360 TSTMIRATAR SAPDRQEEIS KLMRSASFNT DPYVREFGIM VKDEMTDVTG RVLQPPSILY 420 GGRNKAIATP VQGVWDMRNK QFHTGIEIKV WAIACFAPQR QCTEVHLKSF TEQLRKISRD 480 AGMPIQGQPC FCKYAQGADS VEPMFRHLKN TYAGLQLVVV ILPGKTPVYA EVKRVGDTVL 540 GMATQCVQMK NVQRTTPQTL SNLCLKINVK LGGVNNILLP QGRPPVFQQP VIFLGADVTH 600 PPAGDGKKPS IAAVVGSMDA HPNRYCATVR VQQHRQEIIQ DLAAMVRELL IQFYKSTRFK 660 PTRIIFYRDG VSEGQFQQVL HHELLAIREA CIKLEKDYQP GITFIVVQKR HHTRLFCTDK 720 NERVGKSGNI PAGTTVDTKI THPTEFDFYL CSHAGIQGTS RPSHYHVLWD DNRFSSDELQ 780 ILTYQLCHTY VRCTRSVSIP APAYYAHLVA FRARYHLVDK EHDSAEGSHT SGQSNGRDHQ 840 ALAKAVQVHQ DTLRTMYFA |
|
Database | Annotation |
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CTD (Curated) (count: 3) | MESH:D019970
; Cocaine-Related Disorders MESH:D007951 ; Leukemia, Myeloid MESH:C562839 ; Mesothelioma, Malignant |
DisGeNet (Curated) (count: 4) | C0001973; Alcoholic Intoxication, Chronic
C0023470; Myeloid Leukemia C0236736; Cocaine-Related Disorders C0345967; Malignant mesothelioma |
PTM | Modification Sites |
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Phosphorylation (count: 20) (view all) | 153 ALSGRLPSVPFETIQ dbPAF
251 EEQQKPLTDSQRVKF dbPAF 253 QQKPLTDSQRVKFTK dbPAF 303 LQQESGQTVECTVAQ dbPAF 307 SGQTVECTVAQYFKD dbPAF 385 EISKLMRSASFNTDP dbPAF |
Acetylation (count: 4) | 276 ITHCGQMKRKYRVCN PLMD
313 CTVAQYFKDRHKLVL PLMD 62 YHYELDIKPEKCPRR PLMD 720 TRLFCTDKNERVGKS PLMD |
Ubiquitination (count: 9) (view all) | 248 KSIEEQQKPLTDSQR PLMD
381 DRQEEISKLMRSASF PLMD 425 ILYGGRNKAIATPVQ PLMD 533 TPVYAEVKRVGDTVL PLMD 550 ATQCVQMKNVQRTTP PLMD 696 EACIKLEKDYQPGIT PLMD |
Sumoylation (count: 1) | 402 REFGIMVKDEMTDVT PLMD |
Glycation (count: 7) (view all) | 266 TKEIKGLKVEITHCG PLMD
355 AGQRCIKKLTDNQTS PLMD 381 DRQEEISKLMRSASF PLMD 440 GVWDMRNKQFHTGIE PLMD 608 PPAGDGKKPSIAAVV PLMD 693 AIREACIKLEKDYQP PLMD |
Malonylation (count: 2) | 608 PPAGDGKKPSIAAVV PLMD
726 DKNERVGKSGNIPAG PLMD |
Network | Interaction | ||
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A | B | Source | |