| Tag | Content |
|---|---|
| UniProt Accession | TNIK_HUMAN; Q9UKE5; |
| Entrez ID | 23043 |
| GenBank Protein ID | NM_001161560.2; NM_001161561.2; NM_001161562.2; NM_001161563.2; NM_001161564.2; NM_001161565.2; NM_001161566.2; NM_015028.3; |
| GenBank Nucleotide ID | NP_001155032.1; NP_001155033.1; NP_001155034.1; NP_001155035.1; NP_001155036.1; NP_001155037.1; NP_001155038.1; NP_055843.1; |
| Protein Name | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) |
| Gene Name | TNIK; KIAA0551 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. |
| Sequence (Fasta) | MASDSPARSL DEIDLSALRD PAGIFELVEL VGNGTYGQVY KGRHVKTGQL AAIKVMDVTG 60 DEEEEIKQEI NMLKKYSHHR NIATYYGAFI KKNPPGMDDQ LWLVMEFCGA GSVTDLIKNT 120 KGNTLKEEWI AYICREILRG LSHLHQHKVI HRDIKGQNVL LTENAEVKLV DFGVSAQLDR 180 TVGRRNTFIG TPYWMAPEVI ACDENPDATY DFKSDLWSLG ITAIEMAEGA PPLCDMHPMR 240 ALFLIPRNPA PRLKSKKWSK KFQSFIESCL VKNHSQRPAT EQLMKHPFIR DQPNERQVRI 300 QLKDHIDRTK KKRGEKDETE YEYSGSEEEE EENDSGEPSS ILNLPGESTL RRDFLRLQLA 360 NKERSEALRR QQLEQQQREN EEHKRQLLAE RQKRIEEQKE QRRRLEEQQR REKELRKQQE 420 REQRRHYEEQ MRREEERRRA EHEQEYIRRQ LEEEQRQLEI LQQQLLHEQA LLLEYKRKQL 480 EEQRQAERLQ RQLKQERDYL VSLQHQRQEQ RPVEKKPLYH YKEGMSPSEK PAWAKEVEER 540 SRLNRQSSPA MPHKVANRIS DPNLPPRSES FSISGVQPAR TPPMLRPVDP QIPHLVAVKS 600 QGPALTASQS VHEQPTKGLS GFQEALNVTS HRVEMPRQNS DPTSENPPLP TRIEKFDRSS 660 WLRQEEDIPP KVPQRTTSIS PALARKNSPG NGSALGPRLG SQPIRASNPD LRRTEPILES 720 PLQRTSSGSS SSSSTPSSQP SSQGGSQPGS QAGSSERTRV RANSKSEGSP VLPHEPAKVK 780 PEESRDITRP SRPASYKKAI DEDLTALAKE LRELRIEETN RPMKKVTDYS SSSEESESSE 840 EEEEDGESET HDGTVAVSDI PRLIPTGAPG SNEQYNVGMV GTHGLETSHA DSFSGSISRE 900 GTLMIRETSG EKKRSGHSDS NGFAGHINLP DLVQQSHSPA GTPTEGLGRV STHSQEMDSG 960 TEYGMGSSTK ASFTPFVDPR VYQTSPTDED EEDEESSAAA LFTSELLRQE QAKLNEARKI 1020 SVVNVNPTNI RPHSDTPEIR KYKKRFNSEI LCAALWGVNL LVGTENGLML LDRSGQGKVY 1080 NLINRRRFQQ MDVLEGLNVL VTISGKKNKL RVYYLSWLRN RILHNDPEVE KKQGWITVGD 1140 LEGCIHYKVV KYERIKFLVI ALKNAVEIYA WAPKPYHKFM AFKSFADLQH KPLLVDLTVE 1200 EGQRLKVIFG SHTGFHVIDV DSGNSYDIYI PSHIQGNITP HAIVILPKTD GMEMLVCYED 1260 EGVYVNTYGR ITKDVVLQWG EMPTSVAYIH SNQIMGWGEK AIEIRSVETG HLDGVFMHKR 1320 AQRLKFLCER NDKVFFASVR SGGSSQVFFM TLNRNSMMNW 1361 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D020261
; Arsenic Poisoning MESH:D001171 ; Arthritis, Juvenile OMIM:617028 ; MENTAL RETARDATION, AUTOSOMAL RECESSIVE 54 MESH:D012871 ; Skin Diseases |
| DisGeNet (Curated) (count: 4) | C0036341; Schizophrenia
C0037274; Dermatologic disorders C0311375; Arsenic Poisoning C3495559; Juvenile arthritis |
| GWASdb (count: 36) (view all) | rs17826584; Urinary metabolites; kidney disease
rs12494349; Multiple complex diseases; Null rs12494349; Urinary metabolites; kidney disease rs10513691; Urinary metabolites; kidney disease rs16855778; Urinary metabolites; kidney disease rs6781167; Urinary metabolites; kidney disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 77) (view all) | 1034 PTNIRPHSDTPEIRK dbPAF
1036 NIRPHSDTPEIRKYK dbPAF 1116 KLRVYYLSWLRNRIL dbPAF 1351 SSQVFFMTLNRNSMM dbPAF 16 SLDEIDLSALRDPAG dbPAF 181 VSAQLDRTVGRRNTF dbPAF |
| Ubiquitination (count: 3) | 303 RQVRIQLKDHIDRTK PLMD
91 TYYGAFIKKNPPGMD PLMD 92 YYGAFIKKNPPGMDD PLMD |
| Glycation (count: 1) | 67 GDEEEEIKQEINMLK PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |