Q9UJX4

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	APC5_HUMAN; Q9UJX4;
Entrez ID	51433
GenBank Protein ID	NM_001137559.1; NM_001330489.1; NM_016237.4;
GenBank Nucleotide ID	NP_001131031.1; NP_001317418.1; NP_057321.2;
Protein Name	Anaphase-promoting complex subunit 5 (APC5) (Cyclosome subunit 5)
Gene Name	ANAPC5; APC5
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Functional Description Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Sequence (Fasta)	MASVHESLYF NPMMTNGVVH ANVFGIKDWV TPYKIAVLVL LNEMSRTGEG AVSLMERRRL 60 NQLLLPLLQG PDITLSKLYK LIEESCPQLA NSVQIRIKLM AEGELKDMEQ FFDDLSDSFS 120 GTEPEVHKTS VVGLFLRHMI LAYSKLSFSQ VFKLYTALQQ YFQNGEKKTV EDADMELTSR 180 DEGERKMEKE ELDVSVREEE VSCSGPLSQK QAEFFLSQQA SLLKNDETKA LTPASLQKEL 240 NNLLKFNPDF AEAHYLSYLN NLRVQDVFSS THSLLHYFDR LILTGAESKS NGEEGYGRSL 300 RYAALNLAAL HCRFGHYQQA ELALQEAIRI AQESNDHVCL QHCLSWLYVL GQKRSDSYVL 360 LEHSVKKAVH FGLPYLASLG IQSLVQQRAF AGKTANKLMD ALKDSDLLHW KHSLSELIDI 420 SIAQKTAIWR LYGRSTMALQ QAQMLLSMNS LEAVNAGVQQ NNTESFAVAL CHLAELHAEQ 480 GCFAAASEVL KHLKERFPPN SQHAQLWMLC DQKIQFDRAM NDGKYHLADS LVTGITALNS 540 IEGVYRKAVV LQAQNQMSEA HKLLQKLLVH CQKLKNTEMV ISVLLSVAEL YWRSSSPTIA 600 LPMLLQALAL SKEYRLQYLA SETVLNLAFA QLILGIPEQA LSLLHMAIEP ILADGAILDK 660 GRAMFLVAKC QVASAASYDQ PKKAEALEAA IENLNEAKNY FAKVDCKERI RDVVYFQARL 720 YHTLGKTQER NRCAMLFRQL HQELPSHGVP LINHL 756 Fasta Sequence >Q9UJX4\|ANAPC5; APC5\|Homo sapiens (Human) MASVHESLYFNPMMTNGVVHANVFGIKDWVTPYKIAVLVLLNEMSRTGEGAVSLMERRRLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMELTSRDEGERKMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQASLLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEAVNAGVQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELPSHGVPLINHL

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Phosphorylation	Chronic myelogenous leukemia/Chronic myeloid leukemia		A		23707389
1	[Reference]: It evoked the UPR activation leading to the induction of BCL2-interacting mediator of cell death (BIM) by UPR sensors. BIM, in turn, contributed to the execution phase of apoptosis in the activation of ER resident caspase 12 and mobilization of Ca(2+) stores.

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 17) (view all)	15 LYFNPMMTNGVVHAN dbPAF 178 EDADMELTSRDEGER dbPAF 179 DADMELTSRDEGERK dbPAF 195 EKEELDVSVREEEVS dbPAF 202 SVREEEVSCSGPLSQ dbPAF 204 REEEVSCSGPLSQKQ dbPAF 217 KQAEFFLSQQASLLK dbPAF 221 FFLSQQASLLKNDET dbPAF 232 NDETKALTPASLQKE dbPAF 235 TKALTPASLQKELNN dbPAF 255 PDFAEAHYLSYLNNL dbPAF 258 AEAHYLSYLNNLRVQ dbPAF 277 STHSLLHYFDRLILT dbPAF 413 DLLHWKHSLSELIDI dbPAF 421 LSELIDISIAQKTAI dbPAF 47 LLNEMSRTGEGAVSL dbPAF 674 VAKCQVASAASYDQP dbPAF
Acetylation (count: 1)	703 EAKNYFAKVDCKERI PLMD
Ubiquitination (count: 28) (view all)	167 QYFQNGEKKTVEDAD PLMD 168 YFQNGEKKTVEDADM PLMD 210 CSGPLSQKQAEFFLS PLMD 224 SQQASLLKNDETKAL PLMD 229 LLKNDETKALTPASL PLMD 238 LTPASLQKELNNLLK PLMD 245 KELNNLLKFNPDFAE PLMD 289 ILTGAESKSNGEEGY PLMD 353 WLYVLGQKRSDSYVL PLMD 366 VLLEHSVKKAVHFGL PLMD 367 LLEHSVKKAVHFGLP PLMD 393 QQRAFAGKTANKLMD PLMD 397 FAGKTANKLMDALKD PLMD 403 NKLMDALKDSDLLHW PLMD 411 DSDLLHWKHSLSELI PLMD 425 IDISIAQKTAIWRLY PLMD 513 LWMLCDQKIQFDRAM PLMD 524 DRAMNDGKYHLADSL PLMD 547 SIEGVYRKAVVLQAQ PLMD 562 NQMSEAHKLLQKLLV PLMD 669 RAMFLVAKCQVASAA PLMD 682 AASYDQPKKAEALEA PLMD 683 ASYDQPKKAEALEAA PLMD 698 IENLNEAKNYFAKVD PLMD 703 EAKNYFAKVDCKERI PLMD 726 RLYHTLGKTQERNRC PLMD 77 GPDITLSKLYKLIEE PLMD 80 ITLSKLYKLIEESCP PLMD

※ Protein-Protein Interaction

Network

Interaction

A

B

Source

P60484	Q9UJX4	IntAct
Q9HCE7	Q9UJX4	HPRD
Q9UJX4	Q9UJX6	IntAct