| Tag | Content |
|---|---|
| UniProt Accession | DBNL_HUMAN; Q9UJU6; |
| Entrez ID | 28988 |
| GenBank Protein ID | NM_001014436.2; NM_001122956.1; NM_001284313.1; NM_001284315.1; NM_014063.6; |
| GenBank Nucleotide ID | NP_001014436.1; NP_001116428.1; NP_001271242.1; NP_001271244.1; NP_054782.2; |
| Protein Name | Drebrin-like protein (Cervical SH3P7) (Cervical mucin-associated protein) (Drebrin-F) (HPK1-interacting protein of 55 kDa) (HIP-55) (SH3 domain-containing protein 7) |
| Gene Name | DBNL; CMAP; SH3P7; PP5423 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. |
| Sequence (Fasta) | MAANLSRNGP ALQEAYVRVV TEKSPTDWAL FTYEGNSNDI RVAGTGEGGL EEMVEELNSG 60 KVMYAFCRVK DPNSGLPKFV LINWTGEGVN DVRKGACASH VSTMASFLKG AHVTINARAE 120 EDVEPECIME KVAKASGANY SFHKESGRFQ DVGPQAPVGS VYQKTNAVSE IKRVGKDSFW 180 AKAEKEEENR RLEEKRRAEE AQRQLEQERR ERELREAARR EQRYQEQGGE ASPQRTWEQQ 240 QEVVSRNRNE QESAVHPREI FKQKERAMST TSISSPQPGK LRSPFLQKQL TQPETHFGRE 300 PAAAISRPRA DLPAEEPAPS TPPCLVQAEE EAVYEEPPEQ ETFYEQPPLV QQQGAGSEHI 360 DHHIQGQGLS GQGLCARALY DYQAADDTEI SFDPENLITG IEVIDEGWWR GYGPDGHFGM 420 FPANYVELIE 431 |
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| Database | Annotation |
|---|---|
| DisGeNet (Curated) (count: 1) | C0005586; Bipolar Disorder |
| GWASdb (count: 3) | rs4724276; Post-operative nausea and vomiting; Null
rs17136005; Serum metabolites; Null rs7793194; Serum metabolites; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 34) (view all) | 114 FLKGAHVTINARAEE dbPAF
136 MEKVAKASGANYSFH dbPAF 140 AKASGANYSFHKESG dbPAF 141 KASGANYSFHKESGR dbPAF 146 NYSFHKESGRFQDVG dbPAF 16 GPALQEAYVRVVTEK dbPAF |
| Acetylation (count: 7) (view all) | 131 EPECIMEKVAKASGA PLMD
172 TNAVSEIKRVGKDSF PLMD 176 SEIKRVGKDSFWAKA PLMD 23 YVRVVTEKSPTDWAL PLMD 280 ISSPQPGKLRSPFLQ PLMD 288 LRSPFLQKQLTQPET PLMD |
| Ubiquitination (count: 9) (view all) | 134 CIMEKVAKASGANYS PLMD
144 GANYSFHKESGRFQD PLMD 164 PVGSVYQKTNAVSEI PLMD 172 TNAVSEIKRVGKDSF PLMD 176 SEIKRVGKDSFWAKA PLMD 23 YVRVVTEKSPTDWAL PLMD |
| Malonylation (count: 2) | 176 SEIKRVGKDSFWAKA PLMD
280 ISSPQPGKLRSPFLQ PLMD |
| Methylation (count: 1) | 164 PVGSVYQKTNAVSEI PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |