Q9UIK4

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession DAPK2_HUMAN; Q9UIK4;
Entrez ID 23604
GenBank Protein ID NM_014326.3; XM_011521416.2;
GenBank Nucleotide ID NP_055141.2; XP_011519718.1;
Protein Name Death-associated protein kinase 2 (DAP kinase 2) (EC 2.7.11.1) (DAP-kinase-related protein 1) (DRP-1)
Gene Name DAPK2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionCalcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).;Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
Sequence
(Fasta)		MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA AKFIKKRQSR 60
ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV LILELVSGGE LFDFLAQKES 120
LSEEEATSFI KQILDGVNYL HTKKIAHFDL KPENIMLLDK NIPIPHIKLI DFGLAHEIED 180
GVEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT 240
AVSYDFDEEF FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDN QQAMVRRESV 300
VNLENFRKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRP DEDLRNCESD TEEDIARRKA 360
LHPRRRSSTS 371

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationBreast cancer/tumor/carcinomaMCF-7 cell linePS29922580283
[Reference]: Phosphorylation of DAPK2 at Ser299 enhanced its kinase activity, which resulted in inducing apoptosis in MCF-7 cells

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D006529 ; Hepatomegaly
GWASdb
(count: 7)
(view all)		rs9806191; Multiple complex diseases; Null
rs332289; Body mass index; obesity
rs184556; Multiple complex diseases; Null
rs922177; Intelligence (childhood); cognitive disorder
rs427789; Multiple complex diseases; Null
rs395764; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)		 299       QAMVRRESVVNLENF     dbPAF
318       VRRRWKLSFSIVSLC     dbPAF
349       EDLRNCESDTEEDIA     dbPAF
367       ALHPRRRSSTS****     dbPAF
368       LHPRRRSSTS*****     dbPAF
49        EKSTGLEYAAKFIKK     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource