Q9UHH9

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession IP6K2_HUMAN; Q9UHH9;
Entrez ID 51447
GenBank Protein ID NM_001005909.2; NM_001005910.2; NM_001005911.2; NM_001146178.2; NM_001146179.2; NM_001190316.1; NM_001190317.1; NM_016291.3; XM_011533822.1; XM_011533823.1; XM_017006583.1; XM_017006584.1; XM_017006585.1;
GenBank Nucleotide ID NP_001005909.1; NP_001005910.1; NP_001005911.1; NP_001139650.1; NP_001139651.1; NP_001177245.1; NP_001177246.1; NP_057375.2; XP_011532124.1; XP_011532125.1; XP_016862072.1; XP_016862073.1; XP_016862074.1;
Protein Name Inositol hexakisphosphate kinase 2 (InsP6 kinase 2) (EC 2.7.4.21) (P(i)-uptake stimulator) (PiUS)
Gene Name IP6K2; IHPK2; TCCCIA00113
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionConverts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Sequence
(Fasta)		MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 60
KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH 120
VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS 180
MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ 240
IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR 300
RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA 360
DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI 420
SEESGE 427

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationColon cancer/carcinomaPS34721262846
[Reference]: Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D006816 ; Huntington Disease
GWASdb
(count: 3)		rs3172494; Lung adenocarcinoma; lung adenocarcinoma
rs9882443; Heart rate; heart conduction disease
rs11708786; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 5)		 160       LKKSEVLYYTVEKKG     dbPAF
347       RPEVVLDSDAEDLED     dbPAF
356       AEDLEDLSEESADES     dbPAF
359       LEDLSEESADESAGA     dbPAF
87        RNLCLIAYPLKGDHG     dbPAF
Ubiquitination
(count: 24)
(view all)		 129       LETEKTPKDWVRQHR     PLMD
137       DWVRQHRKEEKMKSH     PLMD
140       RQHRKEEKMKSHKLE     PLMD
142       HRKEEKMKSHKLEEE     PLMD
145       EEKMKSHKLEEEFEW     PLMD
15        MDVEPRAKGVLLEPF     PLMD
Sumoylation
(count: 2)		 166       LYYTVEKKGNISSQL     PLMD
236       GDDASEEKAANQIRK     PLMD
Glycation
(count: 2)		 243       KAANQIRKCQQSTSA     PLMD
274       GQLMFMNKYHGRKLS     PLMD