Tag | Content |
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UniProt Accession | TBK1_HUMAN; Q9UHD2; |
Entrez ID | 29110 |
GenBank Protein ID | NM_013254.3; XM_005268809.1; XM_005268810.1; |
GenBank Nucleotide ID | NP_037386.1; XP_005268866.1; XP_005268867.1; |
Protein Name | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (NF-kappa-B-activating kinase) (T2K) (TANK-binding kinase 1) |
Gene Name | TBK1; NAK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 fo(view all) |
Sequence (Fasta) | MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60 KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120 GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL 180 HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG 240 KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA 300 ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV 360 LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG 420 VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK 480 VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE 540 GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH 600 FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ 660 KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD 720 GGLRNVDCL |
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Database | Annotation |
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CTD (Curated) (count: 1) | OMIM:616439 ; FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 4 |
DisGeNet (Curated) (count: 48) (view all) | C0002736; Amyotrophic Lateral Sclerosis
C0003467; Anxiety C0011168; Deglutition Disorders C0011581; Depressive disorder C0013362; Dysarthria C0013404; Dyspnea |
GWASdb (count: 4) | rs11837890; Major depressive disorder (broad); major depressive disorder
rs11829120; Major depressive disorder (broad); major depressive disorder rs7303577; Major depressive disorder (broad); major depressive disorder rs4075094; Major depressive disorder (broad); major depressive disorder |
PTM | Modification Sites |
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Phosphorylation (count: 21) (view all) | 151 VIGEDGQSVYKLTDF dbPAF
153 GEDGQSVYKLTDFGA dbPAF 172 EDDEQFVSLYGTEEY dbPAF 174 DEQFVSLYGTEEYLH dbPAF 179 SLYGTEEYLHPDMYE dbPAF 247 GKPSGAISGVQKAEN dbPAF |
Acetylation (count: 1) | 584 YNEEQIHKFDKQKLY PLMD |
Ubiquitination (count: 15) (view all) | 137 GIVHRDIKPGNIMRV PLMD
154 EDGQSVYKLTDFGAA PLMD 231 FEGPRRNKEVMYKII PLMD 241 MYKIITGKPSGAISG PLMD 251 GAISGVQKAENGPID PLMD 344 ELVYKQTKIISSNQE PLMD |