Q9UHD1

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession CHRD1_HUMAN; Q9UHD1;
Entrez ID 26973
GenBank Protein ID NM_001144073.1; NM_012124.2;
GenBank Nucleotide ID NP_001137545.1; NP_036256.2;
Protein Name Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
Gene Name CHORDC1; CHP1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionRegulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
Sequence
(Fasta)		MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT 60
KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL 120
KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS 180
GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE 240
VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI 300
EITMRKAEPM QWASLELPAA KKQEKQKDAT TD 333

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1GlycosylationNeurodegenerative diseaseC23904602; 3728683
[Reference]: we identified vac as a point mutation in the calcineurin-like EF hand protein 1 (Chp1) gene that resulted in the production of mutant CHP1 isoforms with an amino acid substitution in a functional EF-hand domain or a truncation of this motif by aberrant splicing and significantly reduced protein levels

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs10501713; Stroke; cerebrovascular disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 17)
(view all)		 110       VEAIKRPSPDEPMTN     dbPAF
116       PSPDEPMTNLELKIS     dbPAF
136       ALDKLKLSSGNEENK     dbPAF
137       LDKLKLSSGNEENKK     dbPAF
178       SLEEVCVYHSGVPIF     dbPAF
199       WSCCRRKTSDFNTFL     dbPAF
Acetylation
(count: 13)
(view all)		 101       EHIIQAPKPVEAIKR     PLMD
107       PKPVEAIKRPSPDEP     PLMD
127       LKISASLKQALDKLK     PLMD
132       SLKQALDKLKLSSGN     PLMD
198       YWSCCRRKTSDFNTF     PLMD
215       QEGCTKGKHMWTKKD     PLMD
Ubiquitination
(count: 9)
(view all)		 107       PKPVEAIKRPSPDEP     PLMD
121       PMTNLELKISASLKQ     PLMD
127       LKISASLKQALDKLK     PLMD
198       YWSCCRRKTSDFNTF     PLMD
213       LAQEGCTKGKHMWTK     PLMD
215       QEGCTKGKHMWTKKD     PLMD
Sumoylation
(count: 1)		 89        KKELCELKPKFQEHI     PLMD
Malonylation
(count: 1)		 89        KKELCELKPKFQEHI     PLMD
Succinylation
(count: 1)		 127       LKISASLKQALDKLK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource