Q9UD71

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession PPR1B_HUMAN; Q9UD71;
Entrez ID 84152
GenBank Protein ID NM_001242464.1; NM_032192.3; NM_181505.3; XM_017025216.1; XM_017025217.1;
GenBank Nucleotide ID NP_001229393.1; NP_115568.2; NP_852606.1; XP_016880705.1; XP_016880706.1;
Protein Name Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)
Gene Name PPP1R1B; DARPP32
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionInhibitor of protein-phosphatase 1.
Sequence
(Fasta)		MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPEEE ASPHQRASGE 60
GHHLKSKRPN PCAYTPPSLK AVQRIAESHL QSISNLNENQ ASEEEDELGE LRELGYPREE 120
DEEEEEDDEE EEEEEDSQAE VLKVIRQSAG QKTTCGQGLE GPWERPPPLD ESERDGGSED 180
QVEDPALSEP GEEPQRPSPS EPGT 205

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationAlzheimer's diseaseUT7526178297
[Reference]: Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)		MESH:D002375 ; Catalepsy
MESH:D020820 ; Dyskinesias
GWASdb
(count: 3)		rs2271309; Red blood cell traits; hematopoietic system disease
rs12601930; Triglycerides; coronary artery disease|lipid metabolism disorder|arteriosclerosis
rs907094; Red blood cell traits; hematopoietic system disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 13)
(view all)		 102       NLNENQASEEEDELG     dbPAF
116       GELRELGYPREEDEE     dbPAF
12        DRKKIQFSVPAPPSQ     dbPAF
137       EEEEEEDSQAEVLKV     dbPAF
153       RQSAGQKTTCGQGLE     dbPAF
34        MIRRRRPTPAMLFRL     dbPAF