Tag | Content |
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UniProt Accession | FOXO1_MOUSE; Q9R1E0; |
Entrez ID | 56458 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma) |
Gene Name | Foxo1; Fkhr; Foxo1a |
Organism | Mus musculus |
NCBI Taxa ID | 10090 |
Functional Description | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to s(view all) |
Sequence (Fasta) | MAEAPQVVET DPDFEPLPRQ RSCTWPLPRP EFNQSNSTTS SPAPSGGAAA NPDAAASLAS 60 ASAVSTDFMS NLSLLEESED FARAPGCVAV AAAAAASRGL CGDFQGPEAG CVHPAPPQPP 120 PTGPLSQPPP VPPSAAAAAG PLAGQPRKTS SSRRNAWGNL SYADLITKAI ESSAEKRLTL 180 SQIYEWMVKS VPYFKDKGDS NSSAGWKNSI RHNLSLHSKF IRVQNEGTGK SSWWMLNPEG 240 GKSGKSPRRR AASMDNNSKF AKSRGRAAKK KASLQSGQEG PGDSPGSQFS KWPASPGSHS 300 NDDFDNWSTF RPRTSSNAST ISGRLSPIMT EQDDLGDGDV HSLVYPPSAA KMASTLPSLS 360 EISNPENMEN LLDNLNLLSS PTSLTVSTQS SPGSMMQQTP CYSFAPPNTS LNSPSPNYSK 420 YTYGQSSMSP LPQMPMQTLQ DSKSSYGGLN QYNCAPGLLK ELLTSDSPPH NDIMSPVDPG 480 VAQPNSRVLG QNVMMGPNSV MPAYGSQASH NKMMNPSSHT HPGHAQQTAS VNGRTLPHVV 540 NTMPHTSAMN RLTPVKTPLQ VPLSHPMQMS ALGSYSSVSS CNGYGRMGVL HQEKLPSDLD 600 GMFIERLDCD MESIIRNDLM DGDTLDFNFD NVLPNQSFPH SVKTTTHSWV SG 653 |
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Database | Annotation |
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CTD (Curated) (count: 4) | MESH:D006976
; Hypertension, Pulmonary MESH:D007640 ; Keratoconus MESH:D015470 ; Leukemia, Myeloid, Acute MESH:D018232 ; Rhabdomyosarcoma, Alveolar |
PTM | Modification Sites |
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Phosphorylation (count: 29) (view all) | 24 LPRQRSCTWPLPRPE dbPAF
246 EGGKSGKSPRRRAAS dbPAF 253 SPRRRAASMDNNSKF dbPAF 284 GQEGPGDSPGSQFSK dbPAF 287 GPGDSPGSQFSKWPA dbPAF 295 QFSKWPASPGSHSND dbPAF |
Acetylation (count: 3) | 242 MLNPEGGKSGKSPRR PLMD
245 PEGGKSGKSPRRRAA PLMD 262 DNNSKFAKSRGRAAK PLMD |
Network | Interaction | ||
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A | B | Source | |