Q9R044

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession NPHN_RAT; Q9R044;
Entrez ID 64563
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Nephrin (Renal glomerulus-specific cell adhesion receptor)
Gene Name Nphs1; Nphn
Organism Rattus norvegicus
NCBI Taxa ID 10116
Functional DescriptionSeems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Sequence
(Fasta)
MGAKRVTVRG ARTSPIHRMS SLTPLLLMGM LTSGLAESPV PTSAPRGFWA LSENLTAVEG 60
TTVKLWCGVR APGSVVQWAK DGLLLGPNPK MPGFPRYSLE GDRAKGEFHL LIEACDLSDD 120
AEYECQVGRS ELGPELVSPK VILSILVSPK VLLLTPEAGS TVTWVAGQEY VVTCVSGDAK 180
PAPDITFIQS GRTILDVSSN VNEGSEEKLC ITEAEARVIP QSSDNGQLLV CEGSNPALDT 240
PIKASFTMNI LFPPGPPVID WPGLNEGHVR AGENLELPCT ARGGNPPATL QWLKNGKPVS 300
TAWGTEHAQA VAHSVLVMTV RPEDHGARLS CQSYNSVSAG TQERSITLQV TFPPSAITIL 360
GSVSQSENKN VTLCCLTKSS RPRVLLRWWL GGRQLLPTDE TVMDGLHGGH ISMSNLTFLV 420
RREDNGLPLT CEAFSDAFSK ETFKKSLTLN VKYPAQKLWI EGPPEGQYIR TGTRVRLVCL 480
AIGGNPDPSL IWFKDSRPVS EPRQPQEPRR VQLGSVEKSG STFSRELVLI IGPPDNRAKF 540
SCKAGQLSAS TQLVVQFPPT NLTILANSSA LRPGDALNLT CVSISSNPPV NLSWDKEGER 600
LEDVAAKPQS APFKGSAASR SVFLRVSSRD HGQRVTCRAH SEALRETVSS FYRFNVLYPP 660
EFLGEQVRAV TVVEQGQVLL PVSVSANPAP EAFNWTFRGY RLSPAGGPRH RILSGGALQL 720
WNVTRADDGF YQLHCQNSEG TAEALLKLDV HYAPTIRALR DPTEVNVGGS VDIVCTVDAN 780
PILPEMFSWE RLGEEEEDLN LDDMEKVSKG STGRLRIRQA KLSQAGAYQC IVDNGVAPAA 840
RGLVRLVVRF APQVDQPTPL TKVAAAGDST SSATLHCRAR GVPNIDFTWT KNGVPLDLQD 900
PRYTEHRYHQ GVVHSSLLTI ANVSAAQDYA LFKCTATNAL GSDHTNIQLV SISRPDPPLG 960
LKVVSISPHS VGLEWKPGFD GGLPQRFQIR YEALETPGFL HVDVLPTQAT TFTLTGLKPS 1020
TRYRIWLLAS NALGDSGLTD KGIQVSVTTP GPDQAPEDTD HQLPTELPPG PPRLPLLPVL 1080
FAVGGLLLLS NASCVGGLLW RRRLRRLAEE ISEKTEAGSE DRIRNEYEES QWTGDRDTRS 1140
STVSTAEVDP NYYSMRDFSP QLPPTLEEVL YHQGAEGEDM AFPGHLHDEV ERAYGPPGAW 1200
GPLYDEVRMD PYDLRWPEVQ CEDPRGIYDQ VAADMDAVEA SSLPFELRGH LV 1253

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationKidney diseaseDY120418256598
[Reference]: Before experimental nephrosis, both Y1204 and Y1228 were phosphorylated, and most of the actin was filamentous. Before the onset of overt proteinuria, however, phosphorylation of both Y1204 and Y1228 rapidly decreased and became almost undetectable.?
2Tyrosine PhosphorylationKidney diseaseDY122818256598
[Reference]: however, phosphorylation of both Y1204 and Y1228 rapidly decreased and became almost undetectable.?

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)
MESH:D000419 ; Albuminuria
MESH:D005921 ; Glomerulonephritis
MESH:D005923 ; Glomerulosclerosis, Focal Segmental
MESH:D020138 ; Hyperhomocysteinemia
MESH:D007674 ; Kidney Diseases
MESH:C535761 ; Nephrosis, congenital

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 11)
(view all)
1112      RRLAEEISEKTEAGS     dbPAF
1115      AEEISEKTEAGSEDR     dbPAF
1119      SEKTEAGSEDRIRNE     dbPAF
1127      EDRIRNEYEESQWTG     dbPAF
1152      TAEVDPNYYSMRDFS     dbPAF
1153      AEVDPNYYSMRDFSP     dbPAF