| Tag | Content |
|---|---|
| UniProt Accession | E2AK3_HUMAN; Q9NZJ5; |
| Entrez ID | 9451 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Eukaryotic translation initiation factor 2-alpha kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) |
| Gene Name | EIF2AK3; PEK; PERK |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
| Sequence (Fasta) | MERAISPGLL VRALLLLLLL LGLAARTVAA GRARGLPAPT AEAAFGLGAA AAPTSATRVP 60 AAGAVAAAEV TVEDAEALPA AAGEQEPRGP EPDDETELRP RGRSLVIIST LDGRIAALDP 120 ENHGKKQWDL DVGSGSLVSS SLSKPEVFGN KMIIPSLDGA LFQWDQDRES METVPFTVES 180 LLESSYKFGD DVVLVGGKSL TTYGLSAYSG KVRYICSALG CRQWDSDEME QEEDILLLQR 240 TQKTVRAVGP RSGNEKWNFS VGHFELRYIP DMETRAGFIE STFKPNENTE ESKIISDVEE 300 QEAAIMDIVI KVSVADWKVM AFSKKGGHLE WEYQFCTPIA SAWLLKDGKV IPISLFDDTS 360 YTSNDDVLED EEDIVEAARG ATENSVYLGM YRGQLYLQSS VRISEKFPSS PKALESVTNE 420 NAIIPLPTIK WKPLIHSPSR TPVLVGSDEF DKCLSNDKFS HEEYSNGALS ILQYPYDNGY 480 YLPYYKRERN KRSTQITVRF LDNPHYNKNI RKKDPVLLLH WWKEIVATIL FCIIATTFIV 540 RRLFHPHPHR QRKESETQCQ TENKYDSVSG EANDSSWNDI KNSGYISRYL TDFEPIQCLG 600 RGGFGVVFEA KNKVDDCNYA IKRIRLPNRE LAREKVMREV KALAKLEHPG IVRYFNAWLE 660 APPEKWQEKM DEIWLKDEST DWPLSSPSPM DAPSVKIRRM DPFATKEHIE IIAPSPQRSR 720 SFSVGISCDQ TSSSESQFSP LEFSGMDHED ISESVDAAYN LQDSCLTDCD VEDGTMDGND 780 EGHSFELCPS EASPYVRSRE RTSSSIVFED SGCDNASSKE EPKTNRLHIG NHCANKLTAF 840 KPTSSKSSSE ATLSISPPRP TTLSLDLTKN TTEKLQPSSP KVYLYIQMQL CRKENLKDWM 900 NGRCTIEERE RSVCLHIFLQ IAEAVEFLHS KGLMHRDLKP SNIFFTMDDV VKVGDFGLVT 960 AMDQDEEEQT VLTPMPAYAR HTGQVGTKLY MSPEQIHGNS YSHKVDIFSL GLILFELLYP 1020 FSTQMERVRT LTDVRNLKFP PLFTQKYPCE YVMVQDMLSP SPMERPEAIN IIENAVFEDL 1080 DFPGKTVLRQ RSRSLSSSGT KHSRQSNNSH SPLPSN 1117 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 4) | MESH:D017202
; Myocardial Ischemia MESH:D013226 ; Status Epilepticus MESH:D013494 ; Supranuclear Palsy, Progressive MESH:C536739 ; Wolcott-Rallison syndrome |
| HGMD (count: 17) (view all) | CD042195; Wolcott-Rallison syndrome; Small deletions
CD042196; Wolcott-Rallison syndrome; Small deletions CD032459; Wolcott-Rallison syndrome; Small deletions CD042194; Wolcott-Rallison syndrome; Small deletions CG044323; Wolcott-Rallison syndrome; Gross deletions CP044515; Wolcott-Rallison syndrome; Small indels |
| GWASdb (count: 6) | rs6739095; Urinary metabolites; kidney disease
rs7571971; Progressive supranuclear palsy; progressive supranuclear palsy rs1913671; Urinary metabolites; kidney disease rs867529; Height; Null rs11684404; Height; Null rs11684404; Urinary metabolites; kidney disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 43) (view all) | 1094 VLRQRSRSLSSSGTK dbPAF
1096 RQRSRSLSSSGTKHS dbPAF 1106 GTKHSRQSNNSHSPL dbPAF 1109 HSRQSNNSHSPLPSN dbPAF 1111 RQSNNSHSPLPSN** dbPAF 177 SMETVPFTVESLLES dbPAF |
| Acetylation (count: 1) | 836 IGNHCANKLTAFKPT PLMD |
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