Q9NZC7

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession WWOX_HUMAN; Q9NZC7;
Entrez ID 51741
GenBank Protein ID NM_001291997.1; NM_016373.3; NM_130791.3;
GenBank Nucleotide ID NP_001278926.1; NP_057457.1; NP_570607.1;
Protein Name WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)
Gene Name WWOX; FOR; SDR41C1; WOX1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPutative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Sequence
(Fasta)
MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP 60
YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR 120
DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWHKAKVEAM 180
TLDLALLRSV QHFAEAFKAK NVPLHVLVCN AATFALPWSL TKDGLETTFQ VNHLGHFYLV 240
QLLQDVLCRS APARVIVVSS ESHRFTDIND SLGKLDFSRL SPTKNDYWAM LAYNRSKLCN 300
ILFSNELHRR LSPRGVTSNA VHPGNMMYSN IHRSWWVYTL LFTLARPFTK SMQQGAATTV 360
YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG 415

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationAlzheimer's diseaseDY3315126504
[Reference]: its Tyr33-phosphorylated form, and WOX2 were significantly down-regulated in the neurons of AD hippocampi.
2Tyrosine PhosphorylationSquamous cell carcinomaDY3316115915
[Reference]: Up-regulation of human WOX1, isoform WOX2, and Tyr33 phosphorylation occurred during normal keratinocyte differentiation before cornification and death.
3Tyrosine PhosphorylationParkinson's diseaseUY3318371080
[Reference]: MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1.
4Tyrosine PhosphorylationProstate cancer/carcinoma/adenocarcinomaUY3315580310
[Reference]: These Tyr33-phosphorylated proteins are mostly located in the mitochondria without translocating to the nuclei, which is comparable to those findings in cultured breast cancer cells.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 8)
(view all)
MESH:D001171 ; Arthritis, Juvenile
MESH:D001943 ; Breast Neoplasms
MESH:D002294 ; Carcinoma, Squamous Cell
OMIM:616211 ; EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 28
MESH:C562729 ; Esophageal Squamous Cell Carcinoma
MESH:D020754 ; Spinocerebellar Ataxias
HGMD
(count: 1)
CR084016; Reduced plasma HDL cholesterol, association with; Regulatory
GWASdb
(count: 218)
(view all)
rs11649069; White matter hyperintensity volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy; brain disease|brain ischemia|cerebral arterial disease
rs16947129; Osteoarthritis; osteoarthritis
rs13338697; Blood pressure (response to angiotensin II receptor blocker); hypertension
rs13333314; Blood pressure (response to angiotensin II receptor blocker); hypertension
rs1079572; Lung function (forced vital capacity); lung disease
rs12716850; Pulmonary function (interaction); asthma|chronic obstructive pulmonary disease

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)
111       RQRYDGSTTAMEILQ     dbPAF
12        RYAGLDDTDSEDELP     dbPAF
134       VVVTGANSGIGFETA     dbPAF
14        AGLDDTDSEDELPPG     dbPAF
287       LSPTKNDYWAMLAYN     dbPAF
293       DYWAMLAYNRSKLCN     dbPAF
Ubiquitination
(count: 5)
100       TVDDNPTKPTTRQRY     PLMD
176       LEEWHKAKVEAMTLD     PLMD
274       DINDSLGKLDFSRLS     PLMD
28        GWEERTTKDGWVYYA     PLMD
284       FSRLSPTKNDYWAML     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource