| Tag | Content |
|---|---|
| UniProt Accession | NDE1_HUMAN; Q9NXR1; |
| Entrez ID | 54820 |
| GenBank Protein ID | NM_001143979.1; NM_017668.2; XM_017023349.1; XM_017023356.1; |
| GenBank Nucleotide ID | NP_001137451.1; NP_060138.1; XP_016878838.1; XP_016878845.1; |
| Protein Name | Nuclear distribution protein nudE homolog 1 (NudE) |
| Gene Name | NDE1; NUDE |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post-mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. |
| Sequence (Fasta) | MEDSGKTFSS EEEEANYWKD LAMTYKQRAE NTQEELREFQ EGSREYEAEL ETQLQQIETR 60 NRDLLSENNR LRMELETIKE KFEVQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA 120 NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL 180 AVQQKQEKPR TPMPSSVEAE RTDTAVQATG SVPSTPIAHR GPSSSLNTPG SFRRGLDDST 240 GGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNLVYD QSPNRTGGPA SGRSSKNRDG 300 GERRPSSTSV PLGDKGLGKR LEFGKPPSHM SSSPLPSAQG VVKMLL 347 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 2) | MESH:D054082
; Lissencephaly MESH:C537555 ; Microhydranencephaly |
| GWASdb (count: 9) (view all) | rs4781678; Plasma omega-6 polyunsaturated fatty acid levels; coronary artery disease
rs8061376; Response to taxane treatment (placlitaxel); lung cancer rs7184854; Response to taxane treatment (placlitaxel); lung cancer rs4781679; Response to taxane treatment (placlitaxel); lung cancer rs3784859; Multiple complex diseases; Null rs3784859; Plasma omega-6 polyunsaturated fatty acid levels; coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 33) (view all) | 10 DSGKTFSSEEEEANY dbPAF
131 LERAKRATIMSLEDF dbPAF 165 EKENLLESVQRLKDE dbPAF 191 QKQEKPRTPMPSSVE dbPAF 195 KPRTPMPSSVEAERT dbPAF 196 PRTPMPSSVEAERTD dbPAF |
| Ubiquitination (count: 1) | 270 KVGALESKLASCRNL PLMD |
| Glycation (count: 1) | 6 **MEDSGKTFSSEEE PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |