| Tag | Content |
|---|---|
| UniProt Accession | PARVA_HUMAN; Q9NVD7; |
| Entrez ID | 55742 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) |
| Gene Name | PARVA; MXRA2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. |
| Sequence (Fasta) | MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ EEGMNAINLP 60 LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV LIDWINDVLV GERIIVKDLA 120 EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE IAQKQKLQTV LEKINETLKL PPRSIKWNVD 180 SVHAKSLVAI LHLLVALSQY FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA 240 LSGRHERDAF DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM 300 GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV NCDLKSTLRV 360 LYNLFTKYRN VE 373 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D019966 ; Substance-Related Disorders |
| GWASdb (count: 23) (view all) | rs10219167; Iron levels; iron metabolism disease
rs10219167; Lung function (forced expiratory volume in 1 second); lung disease rs4757420; Osteoarthritis; osteoarthritis rs7941793; Urinary metabolites; kidney disease rs10831809; Type 2 diabetes; type 2 diabetes mellitus rs4485089; Coronary heart disease; coronary artery disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 16) (view all) | 10 TSPQKSPSVPKSPTP dbPAF
124 KDLAEDLYDGQVLQK dbPAF 14 KSPSVPKSPTPKSPP dbPAF 16 PSVPKSPTPKSPPSR dbPAF 167 VLEKINETLKLPPRS dbPAF 174 TLKLPPRSIKWNVDS dbPAF |
| Acetylation (count: 2) | 135 VLQKLFEKLESEKLN PLMD
32 KDDSFLGKLGGTLAR PLMD |
| Ubiquitination (count: 1) | 32 KDDSFLGKLGGTLAR PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |