Q9NRM7

※ Protein Information

Tag	Content
UniProt Accession	LATS2_HUMAN; Q9NRM7;
Entrez ID	26524
GenBank Protein ID	NM_014572.2; XM_005266342.1;
GenBank Nucleotide ID	NP_055387.2; XP_005266399.1;
Protein Name	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene Name	LATS2; KPM
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucle(view all) Functional Description Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Sequence (Fasta)	MRPKTFPATT YSGNSRQRLQ EIREGLKQPS KSSVQGLPAG PNSDTSLDAK VLGSKDATRQ 60 QQQMRATPKF GPYQKALREI RYSLLPFANE SGTSAAAEVN RQMLQELVNA GCDQEMAGRA 120 LKQTGSRSIE AALEYISKMG YLDPRNEQIV RVIKQTSPGK GLMPTPVTRR PSFEGTGDSF 180 ASYHQLSGTP YEGPSFGADG PTALEEMPRP YVDYLFPGVG PHGPGHQHQH PPKGYGASVE 240 AAGAHFPLQG AHYGRPHLLV PGEPLGYGVQ RSPSFQSKTP PETGGYASLP TKGQGGPPGA 300 GLAFPPPAAG LYVPHPHHKQ AGPAAHQLHV LGSRSQVFAS DSPPQSLLTP SRNSLNVDLY 360 ELGSTSVQQW PAATLARRDS LQKPGLEAPP RAHVAFRPDC PVPSRTNSFN SHQPRPGPPG 420 KAEPSLPAPN TVTAVTAAHI LHPVKSVRVL RPEPQTAVGP SHPAWVPAPA PAPAPAPAPA 480 AEGLDAKEEH ALALGGAGAF PLDVEYGGPD RRCPPPPYPK HLLLRSKSEQ YDLDSLCAGM 540 EQSLRAGPNE PEGGDKSRKS AKGDKGGKDK KQIQTSPVPV RKNSRDEEKR ESRIKSYSPY 600 AFKFFMEQHV ENVIKTYQQK VNRRLQLEQE MAKAGLCEAE QEQMRKILYQ KESNYNRLKR 660 AKMDKSMFVK IKTLGIGAFG EVCLACKVDT HALYAMKTLR KKDVLNRNQV AHVKAERDIL 720 AEADNEWVVK LYYSFQDKDS LYFVMDYIPG GDMMSLLIRM EVFPEHLARF YIAELTLAIE 780 SVHKMGFIHR DIKPDNILID LDGHIKLTDF GLCTGFRWTH NSKYYQKGSH VRQDSMEPSD 840 LWDDVSNCRC GDRLKTLEQR ARKQHQRCLA HSLVGTPNYI APEVLLRKGY TQLCDWWSVG 900 VILFEMLVGQ PPFLAPTPTE TQLKVINWEN TLHIPAQVKL SPEARDLITK LCCSADHRLG 960 RNGADDLKAH PFFSAIDFSS DIRKQPAPYV PTISHPMDTS NFDPVDEESP WNDASEGSTK 1020 AWDTLTSPNN KHPEHAFYEF TFRRFFDDNG YPFRCPKPSG AEASQAESSD LESSDLVDQT 1080 EGCQPVYV 1089 Fasta Sequence >Q9NRM7\|LATS2; KPM\|Homo sapiens (Human) MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQMLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGKGLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPGVGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSRSQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Osteogenic sarcoma/Osteosarcoma		A	S835	23886938
1	[Reference]: These results indicate that apoptosis was induced by Lats2-S835D but not by Lats2-WT and Lats2-S835A, suggesting that phosphorylation of S835 on Lats2 promotes apoptosis

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 1)	MESH:D001254 ; Astrocytoma
DisGeNet (Curated) (count: 1)	C0004114; Astrocytoma
GWASdb (count: 10) (view all)	rs507186; Suicide attempts in bipolar disorder; bipolar disorder rs555919; Suicide attempts in bipolar disorder; bipolar disorder rs7990975; Major depressive disorder; major depressive disorder rs688663; Urinary metabolites; kidney disease rs7317623; Suicide attempts in bipolar disorder; bipolar disorder rs1199735; Multiple complex diseases; Null rs9552323; Multiple complex diseases; Null rs11841745; Major depressive disorder; major depressive disorder rs572224; Urinary metabolites; kidney disease rs7139662; Bipolar disorder, schizoaffective; bipolar disorder\|schizoaffective disorder

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 32) (view all)	10 PKTFPATTYSGNSRQ dbPAF 1024 GSTKAWDTLTSPNNK dbPAF 1026 TKAWDTLTSPNNKHP dbPAF 1027 KAWDTLTSPNNKHPE dbPAF 1041 EHAFYEFTFRRFFDD dbPAF 1051 RFFDDNGYPFRCPKP dbPAF 11 KTFPATTYSGNSRQR dbPAF 12 TFPATTYSGNSRQRL dbPAF 135 SIEAALEYISKMGYL dbPAF 172 TPVTRRPSFEGTGDS dbPAF 279 SPSFQSKTPPETGGY dbPAF 286 TPPETGGYASLPTKG dbPAF 288 PETGGYASLPTKGQG dbPAF 342 SQVFASDSPPQSLLT dbPAF 380 ATLARRDSLQKPGLE dbPAF 408 PVPSRTNSFNSHQPR dbPAF 446 HILHPVKSVRVLRPE dbPAF 5 ***MRPKTFPATTYS dbPAF 528 HLLLRSKSEQYDLDS dbPAF 531 LRSKSEQYDLDSLCA dbPAF 535 SEQYDLDSLCAGMEQ dbPAF 543 LCAGMEQSLRAGPNE dbPAF 575 KDKKQIQTSPVPVRK dbPAF 576 DKKQIQTSPVPVRKN dbPAF 598 ESRIKSYSPYAFKFF dbPAF 616 HVENVIKTYQQKVNR dbPAF 690 CLACKVDTHALYAMK dbPAF 82 KALREIRYSLLPFAN dbPAF 829 SKYYQKGSHVRQDSM dbPAF 83 ALREIRYSLLPFANE dbPAF 835 GSHVRQDSMEPSDLW dbPAF 9 RPKTFPATTYSGNSR dbPAF
Acetylation (count: 3)	55 DAKVLGSKDATRQQQ PLMD 570 GDKGGKDKKQIQTSP PLMD 571 DKGGKDKKQIQTSPV PLMD

PTM

Modification Sites

Phosphorylation
(count: 32)
(view all)

10        PKTFPATTYSGNSRQ     dbPAF
1024      GSTKAWDTLTSPNNK     dbPAF
1026      TKAWDTLTSPNNKHP     dbPAF
1027      KAWDTLTSPNNKHPE     dbPAF
1041      EHAFYEFTFRRFFDD     dbPAF
1051      RFFDDNGYPFRCPKP     dbPAF

Acetylation
(count: 3)

55        DAKVLGSKDATRQQQ     PLMD
570       GDKGGKDKKQIQTSP     PLMD
571       DKGGKDKKQIQTSPV     PLMD

※ Protein-Protein Interaction

Network

Interaction

Source

P10276	Q9NRM7	IntAct
Q13188	Q9NRM7	HPRD
Q7L9L4	Q9NRM7	IntAct
Q96IF1	Q9NRM7	HPRD; MINT
Q9H8S9	Q9NRM7	IntAct

PTMD Annotation Information

※ Protein Information

Functional Description

Fasta Sequence

※ PTM-Disease Association

※ Disease Cross-ref Annotation

※ PTM Sites

※ Protein-Protein Interaction