Q9NR19

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession ACSA_HUMAN; Q9NR19;
Entrez ID 55902
GenBank Protein ID NM_001076552.2; NM_018677.3;
GenBank Nucleotide ID NP_001070020.2; NP_061147.1;
Protein Name Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)
Gene Name ACSS2; ACAS2
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionActivates acetate so that it can be used for lipid synthesis or for energy generation.
Sequence
(Fasta)
MGLPEERVRS GSGSRGQEEA GAGGRARSWS PPPEVSRSAH VPSLQRYREL HRRSVEEPRE 60
FWGDIAKEFY WKTPCPGPFL RYNFDVTKGK IFIEWMKGAT TNICYNVLDR NVHEKKLGDK 120
VAFYWEGNEP GETTQITYHQ LLVQVCQFSN VLRKQGIQKG DRVAIYMPMI PELVVAMLAC 180
ARIGALHSIV FAGFSSESLC ERILDSSCSL LITTDAFYRG EKLVNLKELA DEALQKCQEK 240
GFPVRCCIVV KHLGRAELGM GDSTSQSPPI KRSCPDVQIS WNQGIDLWWH ELMQEAGDEC 300
EPEWCDAEDP LFILYTSGST GKPKGVVHTV GGYMLYVATT FKYVFDFHAE DVFWCTADIG 360
WITGHSYVTY GPLANGATSV LFEGIPTYPD VNRLWSIVDK YKVTKFYTAP TAIRLLMKFG 420
DEPVTKHSRA SLQVLGTVGE PINPEAWLWY HRVVGAQRCP IVDTFWQTET GGHMLTPLPG 480
ATPMKPGSAT FPFFGVAPAI LNESGEELEG EAEGYLVFKQ PWPGIMRTVY GNHERFETTY 540
FKKFPGYYVT GDGCQRDQDG YYWITGRIDD MLNVSGHLLS TAEVESALVE HEAVAEAAVV 600
GHPHPVKGEC LYCFVTLCDG HTFSPKLTEE LKKQIREKIG PIATPDYIQN APGLPKTRSG 660
KIMRRVLRKI AQNDHDLGDM STVADPSVIS HLFSHRCLTI Q 702

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationGlioma/Adult gliomasUS65928552616
[Reference]: In addition, ACSS2 S659 phosphorylation positively correlates with AMPK activity in glioma specimens and grades of glioma malignancy.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 2)
rs6088638; Coronary artery disease; coronary artery disease
rs2295097; Protein C levels; protein C deficiency

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 16)
(view all)
10        LPEERVRSGSGSRGQ     dbPAF
100       IEWMKGATTNICYNV     dbPAF
101       EWMKGATTNICYNVL     dbPAF
12        EERVRSGSGSRGQEE     dbPAF
14        RVRSGSGSRGQEEAG     dbPAF
263       AELGMGDSTSQSPPI     dbPAF
Acetylation
(count: 2)
418       TAIRLLMKFGDEPVT     PLMD
632       PKLTEELKKQIREKI     PLMD
Ubiquitination
(count: 6)
227       GEKLVNLKELADEAL     PLMD
236       LADEALQKCQEKGFP     PLMD
271       TSQSPPIKRSCPDVQ     PLMD
418       TAIRLLMKFGDEPVT     PLMD
426       FGDEPVTKHSRASLQ     PLMD
638       LKKQIREKIGPIATP     PLMD
Malonylation
(count: 2)
222       DAFYRGEKLVNLKEL     PLMD
418       TAIRLLMKFGDEPVT     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource