| Tag | Content |
|---|---|
| UniProt Accession | NLRC4_HUMAN; Q9NPP4; |
| Entrez ID | 58484 |
| GenBank Protein ID | NM_001199138.1; NM_001199139.1; NM_001302504.1; NM_021209.4; |
| GenBank Nucleotide ID | NP_001186067.1; NP_001186068.1; NP_001289433.1; NP_067032.3; |
| Protein Name | NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (Clan protein) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf) |
| Gene Name | NLRC4; CARD12; CLAN; CLAN1; IPAF; UNQ6189/PRO20215 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. |
| Sequence (Fasta) | MNFIKDNSRA LIQRMGMTVI KQITDDLFVW NVLNREEVNI ICCEKVEQDA ARGIIHMILK 60 KGSESCNLFL KSLKEWNYPL FQDLNGQSLF HQTSEGDLDD LAQDLKDLYH TPSFLNFYPL 120 GEDIDIIFNL KSTFTEPVLW RKDQHHHRVE QLTLNGLLQA LQSPCIIEGE SGKGKSTLLQ 180 RIAMLWGSGK CKALTKFKFV FFLRLSRAQG GLFETLCDQL LDIPGTIRKQ TFMAMLLKLR 240 QRVLFLLDGY NEFKPQNCPE IEALIKENHR FKNMVIVTTT TECLRHIRQF GALTAEVGDM 300 TEDSAQALIR EVLIKELAEG LLLQIQKSRC LRNLMKTPLF VVITCAIQMG ESEFHSHTQT 360 TLFHTFYDLL IQKNKHKHKG VAASDFIRSL DHCGDLALEG VFSHKFDFEL QDVSSVNEDV 420 LLTTGLLCKY TAQRFKPKYK FFHKSFQEYT AGRRLSSLLT SHEPEEVTKG NGYLQKMVSI 480 SDITSTYSSL LRYTCGSSVE ATRAVMKHLA AVYQHGCLLG LSIAKRPLWR QESLQSVKNT 540 TEQEILKAIN INSFVECGIH LYQESTSKSA LSQEFEAFFQ GKSLYINSGN IPDYLFDFFE 600 HLPNCASALD FIKLDFYGGA MASWEKAAED TGGIHMEEAP ETYIPSRAVS LFFNWKQEFR 660 TLEVTLRDFS KLNKQDIRYL GKIFSSATSL RLQIKRCAGV AGSLSLVLST CKNIYSLMVE 720 ASPLTIEDER HITSVTNLKT LSIHDLQNQR LPGGLTDSLG NLKNLTKLIM DNIKMNEEDA 780 IKLAEGLKNL KKMCLFHLTH LSDIGEGMDY IVKSLSSEPC DLEEIQLVSC CLSANAVKIL 840 AQNLHNLVKL SILDLSENYL EKDGNEALHE LIDRMNVLEQ LTALMLPWGC DVQGSLSSLL 900 KHLEEVPQLV KLGLKNWRLT DTEIRILGAF FGKNPLKNFQ QLNLAGNRVS SDGWLAFMGV 960 FENLKQLVFF DFSTKEFLPD PALVRKLSQV LSKLTFLQEA RLVGWQFDDD DLSVITGAFK 1020 LVTA 1025 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 5) | OMIM:616050
; AUTOINFLAMMATION WITH INFANTILE ENTEROCOLITIS MESH:D056587 ; Cryopyrin-Associated Periodic Syndromes MESH:D004760 ; Enterocolitis MESH:D056660 ; Hereditary Autoinflammatory Diseases MESH:D055501 ; Macrophage Activation Syndrome |
| GWASdb (count: 4) | rs212704; Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); neutropenia
rs212713; Inflammatory biomarkers; Null rs455060; Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); neutropenia rs479333; Inflammatory biomarkers; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 1) | 736 ERHITSVTNLKTLSI dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |