| Tag | Content |
|---|---|
| UniProt Accession | NOX4_HUMAN; Q9NPH5; |
| Entrez ID | 50507 |
| GenBank Protein ID | NM_001143836.2; NM_001143837.1; NM_001291926.1; NM_001291927.1; NM_001300995.1; NM_016931.4; XM_011542857.2; |
| GenBank Nucleotide ID | NP_001137308.1; NP_001137309.1; NP_001278855.1; NP_001278856.1; NP_001287924.1; NP_058627.1; XP_011541159.1; |
| Protein Name | NADPH oxidase 4 (EC 1.6.3.-) (Kidney oxidase-1) (KOX-1) (Kidney superoxide-producing NADPH oxidase) (Renal NAD(P)H-oxidase) |
| Gene Name | NOX4; RENOX |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and isoform 6 display reduced activity.;Isoform 4: Involved in redox signaling in vascular cells. Constitutively and NADPH-dependently generates reactive oxygen species (ROS). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage. Displays an increased activity relative to isoform 1. |
| Sequence (Fasta) | MAVSWRSWLA NEGVKHLCLF IWLSMNVLLF WKTFLLYNQG PEYHYLHQML GLGLCLSRAS 60 ASVLNLNCSL ILLPMCRTLL AYLRGSQKVP SRRTRRLLDK SRTFHITCGV TICIFSGVHV 120 AAHLVNALNF SVNYSEDFVE LNAARYRDED PRKLLFTTVP GLTGVCMVVV LFLMITASTY 180 AIRVSNYDIF WYTHNLFFVF YMLLTLHVSG GLLKYQTNLD THPPGCISLN RTSSQNISLP 240 EYFSEHFHEP FPEGFSKPAE FTQHKFVKIC MEEPRFQANF PQTWLWISGP LCLYCAERLY 300 RYIRSNKPVT IISVMSHPSD VMEIRMVKEN FKARPGQYIT LHCPSVSALE NHPFTLTMCP 360 TETKATFGVH LKIVGDWTER FRDLLLPPSS QDSEILPFIQ SRNYPKLYID GPFGSPFEES 420 LNYEVSLCVA GGIGVTPFAS ILNTLLDDWK PYKLRRLYFI WVCRDIQSFR WFADLLCMLH 480 NKFWQENRPD YVNIQLYLSQ TDGIQKIIGE KYHALNSRLF IGRPRWKLLF DEIAKYNRGK 540 TVGVFCCGPN SLSKTLHKLS NQNNSYGTRF EYNKESFS 579 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 7) (view all) | MESH:D056486
; Chemical and Drug Induced Liver Injury MESH:D003110 ; Colonic Neoplasms MESH:D006333 ; Heart Failure MESH:D006973 ; Hypertension MESH:D007676 ; Kidney Failure, Chronic MESH:D008106 ; Liver Cirrhosis, Experimental |
| GWASdb (count: 32) (view all) | rs3897708; Antineutrophil cytoplasmic antibody-associated vasculitis; vasculitis
rs3897708; Smoking initiation; nicotine dependence rs1847138; Narcolepsy; narcolepsy rs7944576; Prostate cancer; prostate cancer rs10830264; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder rs10830265; Obesity-related traits; obesity |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 1) | 491 WQENRPDYVNIQLYL dbPAF |