| Tag | Content |
|---|---|
| UniProt Accession | SHLB1_MOUSE; Q9JK48; |
| Entrez ID | 54673 |
| GenBank Protein ID | NM_001282037.1; NM_001282042.1; NM_019464.3; |
| GenBank Nucleotide ID | NP_001268966.1; NP_001268971.1; NP_062337.1; |
| Protein Name | Endophilin-B1 (SH3 domain-containing GRB2-like protein B1) |
| Gene Name | Sh3glb1; Kiaa0491 |
| Organism | Mus musculus |
| NCBI Taxa ID | 10090 |
| Functional Description | May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (PubMed:17086176). May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (PubMed:24523556). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activat(view all) |
| Sequence (Fasta) | MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE CTKIWTEKIM 60 KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY MIDAGTEFGP GTAYGNALIK 120 CGETQKRIGT ADRELIQTSA LNFLTPLRNF IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK 180 KAKAAETKSS SEQELRITQS EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ 240 CYQYMLDLQK QLGSFPSNYL SNNNQTSGTP VPYALSNAIG PSAQASTGSL VITCPSNLND 300 LKESSNNRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG NQKGKVPITY 360 LELLN 366 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 2) | 145 TSALNFLTPLRNFIE dbPAF
80 ARIEEFVYEKLDRKA dbPAF |
| Ubiquitination (count: 4) | 10 IMDFNVKKLAADAGT PLMD
355 ERGNQKGKVPITYLE PLMD 61 IWTEKIMKQTEVLLQ PLMD 82 IEEFVYEKLDRKAPS PLMD |