Q9JIY5

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession HTRA2_MOUSE; Q9JIY5;
Entrez ID 64704
GenBank Protein ID
GenBank Nucleotide ID
Protein Name Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI)
Gene Name Htra2; Omi; Prss25
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionSerine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity).
Sequence
(Fasta)		MAALKAGRGA NWSLRAWRAL GGIFWRKPPL LAPDLRALLT SGTPDSQIWM TYGTPSLPAQ 60
VPEGFLASRA DLTSRTPDLW ARLNVGTSGS SDQEARRSPG SRRREWLAVA VGAGGAVVLL 120
LWGWGRGLST VLAAVPAPPP TSPRSQYNFI ADVVEKTAPA VVYIEILDRH PFSGREVPIS 180
NGSGFVVASD GLIVTNAHVV ADRRRVRVRL PSGDTYEAMV TAVDPVADIA TLRIQTKEPL 240
PTLPLGRSAD VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQN NVEYIQTDAA 300
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS WFGTSGSQRR 360
YIGVMMLTLT PSILIELQLR EPSFPDVQHG VLIHKVILGS PAHRAGLRPG DVILAIGEKL 420
AQNAEDVYEA VRTQSQLAVR IRRGSETLTL YVTPEVTE 459

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationParkinson's diseaseDS40021701498
[Reference]: In a murine model G399S mutation had decreased S400 phosphorylation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		OMIM:617248 ; 3-METHYLGLUTACONIC ACIDURIA, TYPE VIII
MESH:D002546 ; Ischemic Attack, Transient
OMIM:610297 ; PARKINSON DISEASE 13, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO
MESH:D020734 ; Parkinsonian Disorders

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 14)
(view all)		 129       WGWGRGLSTVLAAVP     dbPAF
130       GWGRGLSTVLAAVPA     dbPAF
141       AVPAPPPTSPRSQYN     dbPAF
142       VPAPPPTSPRSQYNF     dbPAF
212       RVRVRLPSGDTYEAM     dbPAF
215       VRLPSGDTYEAMVTA     dbPAF
Malonylation
(count: 1)		 348       FLHRGEKKNSWFGTS     PLMD