| Tag | Content |
|---|---|
| UniProt Accession | SMUF1_HUMAN; Q9HCE7; |
| Entrez ID | 57154 |
| GenBank Protein ID | NM_001199847.1; NM_020429.2; NM_181349.2; |
| GenBank Nucleotide ID | NP_001186776.1; NP_065162.1; NP_851994.1; |
| Protein Name | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) |
| Gene Name | SMURF1; KIAA1625 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
| Sequence (Fasta) | MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60 KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120 LNPSDTDAVR GQIVVSLQTR DRIGTGGSVV DCRGLLENEG TVYEDSGPGR PLSCFMEEPA 180 PYTDSTGAAA GGGNCRFVES PSQDQRLQAQ RLRNPDVRGS LQTPQNRPHG HQSPELPEGY 240 EQRTTVQGQV YFLHTQTGVS TWHDPRIPSP SGTIPGGDAA FLYEFLLQGH TSEPRDLNSV 300 NCDELGPLPP GWEVRSTVSG RIYFVDHNNR TTQFTDPRLH HIMNHQCQLK EPSQPLPLPS 360 EGSLEDEELP AQRYERDLVQ KLKVLRHELS LQQPQAGHCR IEVSREEIFE ESYRQIMKMR 420 PKDLKKRLMV KFRGEEGLDY GGVAREWLYL LCHEMLNPYY GLFQYSTDNI YMLQINPDSS 480 INPDHLSYFH FVGRIMGLAV FHGHYINGGF TVPFYKQLLG KPIQLSDLES VDPELHKSLV 540 WILENDITPV LDHTFCVEHN AFGRILQHEL KPNGRNVPVT EENKKEYVRL YVNWRFMRGI 600 EAQFLALQKG FNELIPQHLL KPFDQKELEL IIGGLDKIDL NDWKSNTRLK HCVADSNIVR 660 WFWQAVETFD EERRARLLQF VTGSTRVPLQ GFKALQGSTG AAGPRLFTIH LIDANTDNLP 720 KAHTCFNRID IPPYESYEKL YEKLLTAVEE TCGFAVE 758 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 2) | rs7791007; Gamma gluatamyl transferase levels (interaction with age); alcohol abuse|liver disease
rs6952161; Multiple complex diseases; Null |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 8) (view all) | 200 GNCRFVESPSQDQRL dbPAF
251 TTVQGQVYFLHTQTG dbPAF 260 LHTQTGVSTWHDPRI dbPAF 412 REEIFEESYRQIMKM dbPAF 413 EEIFEESYRQIMKMR dbPAF 526 LGKPIQLSDLESVDP dbPAF |
| Ubiquitination (count: 3) | 350 MNHQCQLKEPSQPLP PLMD
381 YERDLVQKLKVLRHE PLMD 383 RDLVQKLKVLRHELS PLMD |