| Tag | Content |
|---|---|
| UniProt Accession | CYBP_HUMAN; Q9HB71; |
| Entrez ID | 27101 |
| GenBank Protein ID | NM_001007214.1; NM_014412.2; XM_017001046.1; |
| GenBank Nucleotide ID | NP_001007215.1; NP_055227.1; XP_016856535.1; |
| Protein Name | Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein) |
| Gene Name | CACYBP; S100A6BP; SIP; PNAS-107 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). |
| Sequence (Fasta) | MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP 60 AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL 120 NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS 180 YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF 229 |
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| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 19) (view all) | 112 QVHFTERSFDLLVKN dbPAF
125 KNLNGKSYSMIVNNL dbPAF 141 KPISVEGSSKKVKTD dbPAF 142 PISVEGSSKKVKTDT dbPAF 180 CKEKEKPSYDTETDP dbPAF 181 KEKEKPSYDTETDPS dbPAF |
| Acetylation (count: 18) (view all) | 118 RSFDLLVKNLNGKSY PLMD
134 MIVNNLLKPISVEGS PLMD 14 QKDLEEVKVLLEKAT PLMD 143 ISVEGSSKKVKTDTV PLMD 146 EGSSKKVKTDTVLIL PLMD 171 DYLTQVEKECKEKEK PLMD |
| Ubiquitination (count: 24) (view all) | 118 RSFDLLVKNLNGKSY PLMD
123 LVKNLNGKSYSMIVN PLMD 134 MIVNNLLKPISVEGS PLMD 14 QKDLEEVKVLLEKAT PLMD 143 ISVEGSSKKVKTDTV PLMD 144 SVEGSSKKVKTDTVL PLMD |
| Glycation (count: 5) | 143 ISVEGSSKKVKTDTV PLMD
144 SVEGSSKKVKTDTVL PLMD 146 EGSSKKVKTDTVLIL PLMD 207 EDGDDDMKRTINKAW PLMD 33 RDALTAEKSKIETEI PLMD |
| Malonylation (count: 3) | 144 SVEGSSKKVKTDTVL PLMD
146 EGSSKKVKTDTVLIL PLMD 85 YGWDQSDKFVKIYIT PLMD |
| Succinylation (count: 1) | 8 MASEELQKDLEEVKV PLMD |
| Network | Interaction | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| A | B | Source | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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