| Tag | Content |
|---|---|
| UniProt Accession | ECT2_HUMAN; Q9H8V3; |
| Entrez ID | 1894 |
| GenBank Protein ID | NM_001258315.1; NM_001258316.1; NM_018098.5; XM_011512514.2; |
| GenBank Nucleotide ID | NP_001245244.1; NP_001245245.1; NP_060568.3; XP_011510816.1; |
| Protein Name | Protein ECT2 (Epithelial cell-transforming sequence 2 oncogene) |
| Gene Name | ECT2 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equat(view all) |
| Sequence (Fasta) | MAENSVLTST TGRTSLADSS IFDSKVTEIS KENLLIGSTS YVEEEMPQIE TRVILVQEAG 60 KQEELIKALK TIKIMEVPVI KIKESCPGKS DEKLIKSVIN MDIKVGFVKM ESVEEFEGLD 120 SPEFENVFVV TDFQDSVFND LYKADCRVIG PPVVLNCSQK GEPLPFSCRP LYCTSMMNLV 180 LCFTGFRKKE ELVRLVTLVH HMGGVIRKDF NSKVTHLVAN CTQGEKFRVA VSLGTPIMKP 240 EWIYKAWERR NEQDFYAAVD DFRNEFKVPP FQDCILSFLG FSDEEKTNME EMTEMQGGKY 300 LPLGDERCTH LVVEENIVKD LPFEPSKKLY VVKQEWFWGS IQMDARAGET MYLYEKANTP 360 ELKKSVSMLS LNTPNSNRKR RRLKETLAQL SRETDVSPFP PRKRPSAEHS LSIGSLLDIS 420 NTPESSINYG DTPKSCTKSS KSSTPVPSKQ SARWQVAKEL YQTESNYVNI LATIIQLFQV 480 PLEEEGQRGG PILAPEEIKT IFGSIPDIFD VHTKIKDDLE DLIVNWDESK SIGDIFLKYS 540 KDLVKTYPPF VNFFEMSKET IIKCEKQKPR FHAFLKINQA KPECGRQSLV ELLIRPVQRL 600 PSVALLLNDL KKHTADENPD KSTLEKAIGS LKEVMTHINE DKRKTEAQKQ IFDVVYEVDG 660 CPANLLSSHR SLVQRVETIS LGEHPCDRGE QVTLFLFNDC LEIARKRHKV IGTFRSPHGQ 720 TRPPASLKHI HLMPLSQIKK VLDIRETEDC HNAFALLVRP PTEQANVLLS FQMTSDELPK 780 ENWLKMLCRH VANTICKADA ENLIYTADPE SFEVNTKDMD STLSRASRAI KKTSKKVTRA 840 FSFSKTPKRA LRRALMTSHG SVEGRSPSSN DKHVMSRLSS TSSLAGIPSP SLVSLPSFFE 900 RRSHTLSRST THLI 915 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D008106 ; Liver Cirrhosis, Experimental |
| DisGeNet (Curated) (count: 1) | C0023893; Liver Cirrhosis, Experimental |
| GWASdb (count: 1) | rs7646507; Obesity-related traits; obesity |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 58) (view all) | 10 ENSVLTSTTGRTSLA dbPAF
11 NSVLTSTTGRTSLAD dbPAF 14 LTSTTGRTSLADSSI dbPAF 15 TSTTGRTSLADSSIF dbPAF 19 GRTSLADSSIFDSKV dbPAF 24 ADSSIFDSKVTEISK dbPAF |
| Acetylation (count: 1) | 226 ANCTQGEKFRVAVSL PLMD |
| Ubiquitination (count: 15) (view all) | 239 SLGTPIMKPEWIYKA PLMD
25 DSSIFDSKVTEISKE PLMD 299 MTEMQGGKYLPLGDE PLMD 31 SKVTEISKENLLIGS PLMD 384 NRKRRRLKETLAQLS PLMD 449 SSTPVPSKQSARWQV PLMD |
| Sumoylation (count: 6) | 25 DSSIFDSKVTEISKE PLMD
563 MSKETIIKCEKQKPR PLMD 611 ALLLNDLKKHTADEN PLMD 83 EVPVIKIKESCPGKS PLMD 89 IKESCPGKSDEKLIK PLMD 93 CPGKSDEKLIKSVIN PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |