| Tag | Content |
|---|---|
| UniProt Accession | PEAK1_HUMAN; Q9H792; |
| Entrez ID | 79834 |
| GenBank Protein ID | NM_024776.3; XM_005254670.2; XM_005254671.2; XM_005254673.2; XM_005254674.2; XM_005254675.4; XM_011522033.2; XM_011522034.2; XM_011522035.2; XM_011522036.2; XM_011522037.2; XM_011522038.2; XM_011522039.2; |
| GenBank Nucleotide ID | NP_079052.2; XP_005254727.1; XP_005254728.1; XP_005254730.1; XP_005254731.1; XP_005254732.1; XP_011520335.1; XP_011520336.1; XP_011520337.1; XP_011520338.1; XP_011520339.1; XP_011520340.1; XP_011520341.1; |
| Protein Name | Pseudopodium-enriched atypical kinase 1 (EC 2.7.10.2) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) |
| Gene Name | PEAK1; KIAA2002 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. |
| Sequence (Fasta) | MSACNTFTEH VWKPGECKNC FKPKSLHQLP PDPEKAPITH GNVKTNANHS NNHRIRNTGN 60 FRPPVAKKPT IAVKPTMIVA DGQSICGELS IQEHCENKPV IIGWNRNRAA LSQKPLNNNN 120 EDDEGISHVP KPYGNNDSAK KMSDNNNGLT EVLKEIAGLD TAPQIRGNET NSRETFLGRI 180 NDCYKRSLER KLPPSCMIGG IKETQGKHVI LSGSTEVISN EGGRFCYPEF SSGEESEEDV 240 LFSNMEEEHE SWDESDEELL AMEIRMRGQP RFANFRANTL SPVRFFVDKK WNTIPLRNKS 300 LQRICAVDYD DSYDEILNGY EENSVVSYGQ GSIQSMVSSD STSPDSSLTE ESRSETASSL 360 SQKICNGGLS PGNPGDSKDM KEIEPNYESP SSNNQDKDSS QASKSSIKVP ETHKAVLALR 420 LEEKDGKIAV QTEKEESKAS TDVAGQAVTI NLVPTEEQAK PYRVVNLEQP LCKPYTVVDV 480 SAAMASEHLE GPVNSPKTKS SSSTPNSPVT SSSLTPGQIS AHFQKSSAIR YQEVWTSSTS 540 PRQKIPKVEL ITSGTGPNVP PRKNCHKSAP TSPTATNISS KTIPVKSPNL SEIKFNSYNN 600 AGMPPFPIII HDEPTYARSS KNAIKVPIVI NPNAYDNLAI YKSFLGTSGE LSVKEKTTSV 660 ISHTYEEIET ESKVPDNTTS KTTDCLQTKG FSNSTEHKRG SVAQKVQEFN NCLNRGQSSP 720 QRSYSSSHSS PAKIQRATQE PVAKIEGTQE SQMVGSSSTR EKASTVLSQI VASIQPPQSP 780 PETPQSGPKA CSVEELYAIP PDADVAKSTP KSTPVRPKSL FTSQPSGEAE APQTTDSPTT 840 KVQKDPSIKP VTPSPSKLVT SPQSEPPAPF PPPRSTSSPY HAGNLLQRHF TNWTKPTSPT 900 RSTEAESVLH SEGSRRAADA KPKRWISFKS FFRRRKTDEE DDKEKEREKG KLVGLDGTVI 960 HMLPPPPVQR HHWFTEAKGE SSEKPAIVFM YRCDPAQGQL SVDQSKARTD QAAVMEKGRA 1020 ENALLQDSEK KRSHSSPSQI PKKILSHMTH EVTEDFSPRD PRTVVGKQDG RGCTSVTTAL 1080 SLPELEREDG KEDISDPMDP NPCSATYSNL GQSRAAMIPP KQPRQPKGAV DDAIAFGGKT 1140 DQEAPNASQP TPPPLPKKMI IRANTEPISK DLQKSMESSL CVMANPTYDI DPNWDASSAG 1200 SSISYELKGL DIESYDSLER PLRKERPVPS AANSISSLTT LSIKDRFSNS MESLSSRRGP 1260 SCRQGRGIQK PQRQALYRGL ENREEVVGKI RSLHTDALKK LAVKCEDLFM AGQKDQLRFG 1320 VDSWSDFRLT SDKPCCEAGD AVYYTASYAK DPLNNYAVKI CKSKAKESQQ YYHSLAVRQS 1380 LAVHFNIQQD CGHFLAEVPN RLLPWEDPDD PEKDEDDMEE TEEDAKGETD GKNPKPCSEA 1440 ASSQKENQGV MSKKQRSHVV VITREVPCLT VADFVRDSLA QHGKSPDLYE RQVCLLLLQL 1500 CSGLEHLKPY HVTHCDLRLE NLLLVHYQPG GTAQGFGPAE PSPTSSYPTR LIVSNFSQAK 1560 QKSHLVDPEI LRDQSRLAPE IITATQYKKC DEFQTGILIY EMLHLPNPFD ENPELKEREY 1620 TRADLPRIPF RSPYSRGLQQ LASCLLNPNP SERILISDAK GILQCLLWGP REDLFQTFTA 1680 CPSLVQRNTL LQNWLDIKRT LLMIKFAEKS LDREGGISLE DWLCAQYLAF ATTDSLSCIV 1740 KILQHR 1747 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 18) (view all) | rs4886850; Type 2 diabetes; type 2 diabetes mellitus
rs1446312; Type 2 diabetes; type 2 diabetes mellitus rs12909704; Rheumatoid arthritis; rheumatoid arthritis rs4243045; Type 2 diabetes; type 2 diabetes mellitus rs11630770; Multiple complex diseases; Null rs11856513; Lymphocyte counts; asthma|leukemia|lymphoma|lymphopenia|cardiovascular system disease |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 123) (view all) | 1035 SEKKRSHSSPSQIPK dbPAF
1036 EKKRSHSSPSQIPKK dbPAF 1038 KRSHSSPSQIPKKIL dbPAF 1046 QIPKKILSHMTHEVT dbPAF 1057 HEVTEDFSPRDPRTV dbPAF 1074 KQDGRGCTSVTTALS dbPAF |
| Ubiquitination (count: 3) | 1224 SLERPLRKERPVPSA PLMD
1333 DFRLTSDKPCCEAGD PLMD 1426 EETEEDAKGETDGKN PLMD |
| Malonylation (count: 3) | 1289 NREEVVGKIRSLHTD PLMD
1484 DSLAQHGKSPDLYER PLMD 1560 VSNFSQAKQKSHLVD PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |