Q9EQW6

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	OLIG2_MOUSE; Q9EQW6;
Entrez ID	50913
GenBank Protein ID
GenBank Nucleotide ID
Protein Name	Oligodendrocyte transcription factor 2 (Oligo2)
Gene Name	Olig2
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. Functional Description Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
Sequence (Fasta)	MDSDASLVSS RPSSPEPDDL FLPARSKGGS SSGFTGGTVS SSTPSDCPPE LSSELRGAMG 60 ASGAHPGDKL GGGGFKSSSS STSSSTSSAA TSSTKKDKKQ MTEPELQQLR LKINSRERKR 120 MHDLNIAMDG LREVMPYAHG PSVRKLSKIA TLLLARNYIL MLTNSLEEMK RLVSEIYGGH 180 HAGFHPSACG GLAHSAPLPT ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS 240 ASLPGSGLSS VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG GSGGFQHWGG MPCPCSMCQV 300 PPPHHHVSAM GAGTLPRLTS DAK 324 Fasta Sequence >Q9EQW6\|Olig2\|Mus musculus (Mouse) MDSDASLVSSRPSSPEPDDLFLPARSKGGSSSGFTGGTVSSSTPSDCPPELSSELRGAMGASGAHPGDKLGGGGFKSSSSSTSSSTSSAATSSTKKDKKQMTEPELQQLRLKINSRERKRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTNSLEEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPTATAHPAAAAHAAHHPAVHHPILPPAAAAAAAAAAAAAVSSASLPGSGLSSVGSIRPPHGLLKSPSAAAAAPLGGGGGGSGGSGGFQHWGGMPCPCSMCQVPPPHHHVSAMGAGTLPRLTSDAK

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Glioma/Adult gliomas		U	S10	28355568
1	[Reference]: The mitogenic/gliomagenic functions of Olig2 are regulated by phosphorylation of a triple serine motif (S10, S13, and S14) in the amino terminus.we show that small molecule inhibitors of this forward-feeding phosphorylation cascade have potential as glioma therapeutics
2	Serine Phosphorylation	Glioma/Adult gliomas		U	S13	28355568
2	[Reference]: A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.
3	Serine Phosphorylation	Glioma/Adult gliomas		U	S14	28355568
3	[Reference]: The mitogenic/gliomagenic functions of Olig2 are regulated by phosphorylation of a triple serine motif (S10, S13, and S14) in the amino terminus.

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 5)	10 SDASLVSSRPSSPEP dbPAF 13 SLVSSRPSSPEPDDL dbPAF 14 LVSSRPSSPEPDDLF dbPAF 147 GPSVRKLSKIATLLL dbPAF 43 GGTVSSSTPSDCPPE dbPAF