Q9D1F4

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession AKTS1_MOUSE; Q9D1F4;
Entrez ID 67605
GenBank Protein ID NM_001253920.1; NM_001290694.1; NM_001290695.1; NM_026270.4; XM_006541119.3; XM_006541120.3; XM_006541121.3; XM_006541122.2;
GenBank Nucleotide ID NP_001240849.1; NP_001277623.1; NP_001277624.1; NP_080546.1; XP_006541182.1; XP_006541183.1; XP_006541184.1; XP_006541185.1;
Protein Name Proline-rich AKT1 substrate 1 (Proline-rich AKT substrate)
Gene Name Akt1s1; Pras
Organism Mus musculus
NCBI Taxa ID 10090
Functional DescriptionSubunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein(view all)
Sequence
(Fasta)
MASGRPEELW EAVVGAAERF QARTGTELVL LTAAPPPPPR PGPCAYAAHG RGALAEAARR 60
CLHDIAQAHR AATATRPPGP PPAPQPPSPA PSPPPRPALA REDEEEDEDE PTETETSGER 120
LGGSDNGGLF MMDEDATLQD LPPFCESDPE STDDGSLSEE TPAGPTACPQ PPATALPTQQ 180
YAKSLPVSVP VWAFKEKRTE ARSSDEENGP PSSPDLDRIA ASMRALVLRE AEDTQVFGDL 240
PRPRLNTSDF QKLKRKY 258

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Threonine PhosphorylationDiabetes mellitusDT24717130464
[Reference]: Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 2)
MESH:D015427 ; Reperfusion Injury
MESH:D013119 ; Spinal Cord Injuries

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 15)
(view all)
117       EPTETETSGERLGGS     dbPAF
184       PTQQYAKSLPVSVPV     dbPAF
199       WAFKEKRTEARSSDE     dbPAF
203       EKRTEARSSDEENGP     dbPAF
204       KRTEARSSDEENGPP     dbPAF
212       DEENGPPSSPDLDRI     dbPAF