| Tag | Content |
|---|---|
| UniProt Accession | SRCN1_HUMAN; Q9C0H9; |
| Entrez ID | 80725 |
| GenBank Protein ID | |
| GenBank Nucleotide ID | |
| Protein Name | SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap) |
| Gene Name | SRCIN1; KIAA1684; P140 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance. |
| Sequence (Fasta) | MRGAWVHLHS GAASSLRPCR CGAGAAPKSS PRSPGGRRGD GSSDSEGGVS FAGVLFLQFG 60 EETRRVHITH EVSSLDTLHA LIAHMFPQKL TMGMLKSPNT AILIKDEARN VFYELEDVRD 120 IQDRSIIKIY RKEPLYAAFP GSHLTNGDLR REMVYASRES SPTRRLNNLS PAPHLASGSP 180 PPGLPSGLPS GLQSGSPSRS RLSYAGGRPP SYAGSPVHHA AERLGGAPAA QGVSPSPSAI 240 LERRDVKPDE DLASKAGGMV LVKGEGLYAD PYGLLHEGRL SLAAAAGDPF AYPGAGGLYK 300 RGSVRSLSTY SAAALQSDLE DSLYKAAGGG GPLYGDGYGF RLPPSSPQKL ADVAAPPGGP 360 PPPHSPYSGP PSRGSPVRQS FRKDSGSSSV FAESPGGKTR SAGSASTAGA PPSELFPGPG 420 ERSLVGFGPP VPAKDTETRE RMEAMEKQIA SLTGLVQSAL LRGSEPETPS EKIEGSNGAA 480 TPSAPCGSGG RSSGATPVSG PPPPSASSTP AGQPTAVSRL QMQLHLRGLQ NSASDLRGQL 540 QQLRKLQLQN QESVRALLKR TEAELSMRVS EAARRQEDPL QRQRTLVEEE RLRYLNDEEL 600 ITQQLNDLEK SVEKIQRDVS HNHRLVPGPE LEEKALVLKQ LGETLTELKA HFPGLQSKMR 660 VVLRVEVEAV KFLKEEPQRL DGLLKRCRGV TDTLAQIRRQ VDEGVWPPPN NLLSQSPKKV 720 TAETDFNKSV DFEMPPPSPP LNLHELSGPA EGASLTPKGG NPTKGLDTPG KRSVDKAVSV 780 EAAERDWEEK RAALTQYSAK DINRLLEETQ AELLKAIPDL DCASKAHPGP APTPDHKPPK 840 APHGQKAAPR TEPSGRRGSD ELTVPRYRTE KPSKSPPPPP PRRSFPSSHG LTTTRTGEVV 900 VTSKKDSAFI KKAESEELEV QKPQVKLRRA VSEVARPAST PPIMASAIKD EDDEDRIIAE 960 LESGGGSVPP MKVVTPGASR LKAAQGQAGS PDKSKHGKQR AEYMRIQAQQ QATKPSKEMS 1020 GSNETSSPVS EKPSASRTSI PVLTSFGARN SSISF 1056 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 1) | rs3892952; Systemic lupus erythematosus; systemic lupus erythematosus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 47) (view all) | 100 GMLKSPNTAILIKDE dbPAF
1044 RTSIPVLTSFGARNS dbPAF 136 IYRKEPLYAAFPGSH dbPAF 155 DLRREMVYASRESSP dbPAF 177 SPAPHLASGSPPPGL dbPAF 179 APHLASGSPPPGLPS dbPAF |
| Methylation (count: 1) | 719 LLSQSPKKVTAETDF PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |