Tag | Content |
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UniProt Accession | PINK1_HUMAN; Q9BXM7; |
Entrez ID | 65018 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1) |
Gene Name | PINK1 |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). |
Sequence (Fasta) | MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG 60 LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR 120 AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ 180 NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE 240 LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP 300 SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH 360 RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST 420 ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP 480 DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL 540 ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L 582 |
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Database | Annotation |
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CTD (Curated) (count: 5) | MESH:D009410
; Nerve Degeneration MESH:D009447 ; Neuroblastoma MESH:D010300 ; Parkinson Disease MESH:C565276 ; Parkinson Disease 6, Autosomal Recessive Early-Onset MESH:D020734 ; Parkinsonian Disorders |
HGMD (count: 79) (view all) | CD061455; Parkinson disease, early-onset; Small deletions
CD083339; Parkinson disease, autosomal recessive; Small deletions CD083340; Parkinson disease, early-onset; Small deletions CD061456; Parkinson disease, early-onset; Small deletions CG052747; Parkinson disease, early-onset; Gross deletions CG092706; Parkinson disease, early-onset; Gross deletions |
GWASdb (count: 4) | rs3820321; Type 2 diabetes; type 2 diabetes mellitus
rs2298298; Personality dimensions; personality disorder rs3102071; Personality dimensions; personality disorder rs2298299; Acute lung injury; lung disease |
PTM | Modification Sites |
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Phosphorylation (count: 4) | 228 MWNISAGSSSEAILN dbPAF
257 AGEYGAVTYRKSKRG dbPAF 313 EGLGHGRTLFLVMKN dbPAF 402 GLQLPFSSWYVDRGG dbPAF |
Ubiquitination (count: 3) | 186 PQNLEVTKSTGLLPG PLMD
24 LLLRFTGKPGRAYGL PLMD 319 RTLFLVMKNYPCTLR PLMD |
Network | Interaction | ||
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A | B | Source | |