Tag | Content |
---|---|
UniProt Accession | BBC3_HUMAN; Q9BXH1; |
Entrez ID | 27113 |
GenBank Protein ID | NM_001127240.2; NM_001127241.2; NM_001127242.2; NM_014417.4; XM_006723141.3; |
GenBank Nucleotide ID | NP_001120712.1; NP_001120713.1; NP_001120714.1; NP_055232.1; XP_006723204.1; |
Protein Name | Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis) |
Gene Name | BBC3; PUMA |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. |
Sequence (Fasta) | MARARQEGSS PEPVEGLARD GPRPFPLGRL VPSAVSCGLC EPGLAAAPAA PTLLPAAYLC 60 APTAPPAVTA ALGGSRWPGG PRSRPRGPRP DGPQPSLSLA EQHLESPVPS APGALAGGPT 120 QAAPGVRGEE EQWAREIGAQ LRRMADDLNA QYERRRQEEQ QRHRPSPWRV LYNLIMGLLP 180 LPRGHRAPEM EPN 194 |
|
Database | Annotation |
---|---|
CTD (Curated) (count: 4) | MESH:D002545
; Brain Ischemia MESH:D002051 ; Burkitt Lymphoma MESH:D004938 ; Esophageal Neoplasms MESH:D008114 ; Liver Neoplasms, Experimental |
DisGeNet (Curated) (count: 3) | C0006413; Burkitt Lymphoma
C0007786; Brain Ischemia C0014859; Esophageal Neoplasms |
GWASdb (count: 1) | rs2032809; LDL lipoproteins; atherosclerosis |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 8) (view all) | 10 RARQEGSSPEPVEGL dbPAF
106 LAEQHLESPVPSAPG dbPAF 152 ADDLNAQYERRRQEE dbPAF 166 EQQRHRPSPWRVLYN dbPAF 172 PSPWRVLYNLIMGLL dbPAF 58 PTLLPAAYLCAPTAP dbPAF |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |