Q9BXH1

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession BBC3_HUMAN; Q9BXH1;
Entrez ID 27113
GenBank Protein ID NM_001127240.2; NM_001127241.2; NM_001127242.2; NM_014417.4; XM_006723141.3;
GenBank Nucleotide ID NP_001120712.1; NP_001120713.1; NP_001120714.1; NP_055232.1; XP_006723204.1;
Protein Name Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis)
Gene Name BBC3; PUMA
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionEssential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
Sequence
(Fasta)		MARARQEGSS PEPVEGLARD GPRPFPLGRL VPSAVSCGLC EPGLAAAPAA PTLLPAAYLC 60
APTAPPAVTA ALGGSRWPGG PRSRPRGPRP DGPQPSLSLA EQHLESPVPS APGALAGGPT 120
QAAPGVRGEE EQWAREIGAQ LRRMADDLNA QYERRRQEEQ QRHRPSPWRV LYNLIMGLLP 180
LPRGHRAPEM EPN 194

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationBreast cancer/tumor/carcinomaMCF7 cell linePY58/152/17224236056
[Reference]: HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 4)		MESH:D002545 ; Brain Ischemia
MESH:D002051 ; Burkitt Lymphoma
MESH:D004938 ; Esophageal Neoplasms
MESH:D008114 ; Liver Neoplasms, Experimental
DisGeNet (Curated)
(count: 3)		C0006413; Burkitt Lymphoma
C0007786; Brain Ischemia
C0014859; Esophageal Neoplasms
GWASdb
(count: 1)		rs2032809; LDL lipoproteins; atherosclerosis

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)		 10        RARQEGSSPEPVEGL     dbPAF
106       LAEQHLESPVPSAPG     dbPAF
152       ADDLNAQYERRRQEE     dbPAF
166       EQQRHRPSPWRVLYN     dbPAF
172       PSPWRVLYNLIMGLL     dbPAF
58        PTLLPAAYLCAPTAP     dbPAF

※ Protein-Protein Interaction

NetworkInteraction
ABSource