Tag | Content |
---|---|
UniProt Accession | PHF20_HUMAN; Q9BVI0; |
Entrez ID | 51230 |
GenBank Protein ID | NM_016436.4; XM_017027864.1; XM_017027865.1; XM_017027866.1; XM_017027867.1; |
GenBank Nucleotide ID | NP_057520.2; XP_016883353.1; XP_016883354.1; XP_016883355.1; XP_016883356.1; |
Protein Name | PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP) |
Gene Name | PHF20; C20orf104; GLEA2; HCA58; NZF; TZP |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. |
Sequence (Fasta) | MTKHPPNRRG ISFEVGAQLE ARDRLKNWYP AHIEDIDYEE GKVLIHFKRW NHRYDEWFCW 60 DSPYLRPLEK IQLRKEGLHE EDGSSEFQIN EQVLACWSDC RFYPAKVTAV NKDGTYTVKF 120 YDGVVQTVKH IHVKAFSKDQ NIVGNARPKE TDHKSLSSSP DKREKFKEQR KATVNVKKDK 180 EDKPLKTEKR PKQPDKEGKL ICSEKGKVSE KSLPKNEKED KENISENDRE YSGDAQVDKK 240 PENDIVKSPQ ENLREPKRKR GRPPSIAPTA VDSNSQTLQP ITLELRRRKI SKGCEVPLKR 300 PRLDKNSSQE KSKNYSENTD KDLSRRRSSR LSTNGTHEIL DPDLVVSDLV DTDPLQDTLS 360 STKESEEGQL KSALEAGQVS SALTCHSFGD GSGAAGLELN CPSMGENTMK TEPTSPLVEL 420 QEISTVEVTN TFKKTDDFGS SNAPAVDLDH KFRCKVVDCL KFFRKAKLLH YHMKYFHGME 480 KSLEPEESPG KRHVQTRGPS ASDKPSQETL TRKRVSASSP TTKDKEKNKE KKFKEFVRVK 540 PKKKKKKKKK TKPECPCSEE ISDTSQEPSP PKAFAVTRCG SSHKPGVHMS PQLHGPESGH 600 HKGKVKALEE DNLSESSSES FLWSDDEYGQ DVDVTTNPDE ELDGDDRYDF EVVRCICEVQ 660 EENDFMIQCE ECQCWQHGVC MGLLEENVPE KYTCYVCQDP PGQRPGFKYW YDKEWLSRGH 720 MHGLAFLEEN YSHQNAKKIV ATHQLLGDVQ RVIEVLHGLQ LKMSILQSRE HPDLPLWCQP 780 WKQHSGEGRS HFRNIPVTDT RSKEEAPSYR TLNGAVEKPR PLALPLPRSV EESYITSEHC 840 YQKPRAYYPA VEQKLVVETR GSALDDAVNP LHENGDDSLS PRLGWPLDQD RSKGDSDPKP 900 GSPKVKEYVS KKALPEEAPA RKLLDRGGEG LLSSQHQWQF NLLTHVESLQ DEVTHRMDSI 960 EKELDVLESW LDYTGELEPP EPLARLPQLK HCIKQLLMDL GKVQQIALCC ST 1013 |
|
Database | Annotation |
---|---|
GWASdb (count: 17) (view all) | rs11906854; Migraine - clinic-based; migraine
rs17430100; Protein C levels; protein C deficiency rs6060612; Common traits (Other); Null rs17345771; Protein C levels; protein C deficiency rs2425168; Protein C levels; protein C deficiency rs2425173; Protein C levels; protein C deficiency |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 33) (view all) | 103 CWSDCRFYPAKVTAV dbPAF
116 AVNKDGTYTVKFYDG dbPAF 158 TDHKSLSSSPDKREK dbPAF 159 DHKSLSSSPDKREKF dbPAF 209 CSEKGKVSEKSLPKN dbPAF 225 KEDKENISENDREYS dbPAF |
Acetylation (count: 13) (view all) | 205 GKLICSEKGKVSEKS PLMD
211 EKGKVSEKSLPKNEK PLMD 299 KGCEVPLKRPRLDKN PLMD 321 NYSENTDKDLSRRRS PLMD 467 LKFFRKAKLLHYHMK PLMD 491 EPEESPGKRHVQTRG PLMD |
Ubiquitination (count: 8) (view all) | 1002 QLLMDLGKVQQIALC PLMD
180 TVNVKKDKEDKPLKT PLMD 183 VKKDKEDKPLKTEKR PLMD 48 GKVLIHFKRWNHRYD PLMD 713 GFKYWYDKEWLSRGH PLMD 818 TLNGAVEKPRPLALP PLMD |
Sumoylation (count: 3) | 240 GDAQVDKKPENDIVK PLMD
803 PVTDTRSKEEAPSYR PLMD 854 YYPAVEQKLVVETRG PLMD |
Glycation (count: 1) | 818 TLNGAVEKPRPLALP PLMD |
Methylation (count: 1) | 177 RKATVNVKKDKEDKP PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |