Q9BVI0

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PHF20_HUMAN; Q9BVI0;
Entrez ID 51230
GenBank Protein ID NM_016436.4; XM_017027864.1; XM_017027865.1; XM_017027866.1; XM_017027867.1;
GenBank Nucleotide ID NP_057520.2; XP_016883353.1; XP_016883354.1; XP_016883355.1; XP_016883356.1;
Protein Name PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)
Gene Name PHF20; C20orf104; GLEA2; HCA58; NZF; TZP
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionMethyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.
Sequence
(Fasta)
MTKHPPNRRG ISFEVGAQLE ARDRLKNWYP AHIEDIDYEE GKVLIHFKRW NHRYDEWFCW 60
DSPYLRPLEK IQLRKEGLHE EDGSSEFQIN EQVLACWSDC RFYPAKVTAV NKDGTYTVKF 120
YDGVVQTVKH IHVKAFSKDQ NIVGNARPKE TDHKSLSSSP DKREKFKEQR KATVNVKKDK 180
EDKPLKTEKR PKQPDKEGKL ICSEKGKVSE KSLPKNEKED KENISENDRE YSGDAQVDKK 240
PENDIVKSPQ ENLREPKRKR GRPPSIAPTA VDSNSQTLQP ITLELRRRKI SKGCEVPLKR 300
PRLDKNSSQE KSKNYSENTD KDLSRRRSSR LSTNGTHEIL DPDLVVSDLV DTDPLQDTLS 360
STKESEEGQL KSALEAGQVS SALTCHSFGD GSGAAGLELN CPSMGENTMK TEPTSPLVEL 420
QEISTVEVTN TFKKTDDFGS SNAPAVDLDH KFRCKVVDCL KFFRKAKLLH YHMKYFHGME 480
KSLEPEESPG KRHVQTRGPS ASDKPSQETL TRKRVSASSP TTKDKEKNKE KKFKEFVRVK 540
PKKKKKKKKK TKPECPCSEE ISDTSQEPSP PKAFAVTRCG SSHKPGVHMS PQLHGPESGH 600
HKGKVKALEE DNLSESSSES FLWSDDEYGQ DVDVTTNPDE ELDGDDRYDF EVVRCICEVQ 660
EENDFMIQCE ECQCWQHGVC MGLLEENVPE KYTCYVCQDP PGQRPGFKYW YDKEWLSRGH 720
MHGLAFLEEN YSHQNAKKIV ATHQLLGDVQ RVIEVLHGLQ LKMSILQSRE HPDLPLWCQP 780
WKQHSGEGRS HFRNIPVTDT RSKEEAPSYR TLNGAVEKPR PLALPLPRSV EESYITSEHC 840
YQKPRAYYPA VEQKLVVETR GSALDDAVNP LHENGDDSLS PRLGWPLDQD RSKGDSDPKP 900
GSPKVKEYVS KKALPEEAPA RKLLDRGGEG LLSSQHQWQF NLLTHVESLQ DEVTHRMDSI 960
EKELDVLESW LDYTGELEPP EPLARLPQLK HCIKQLLMDL GKVQQIALCC ST 1013

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationUrethral cancerUS29122975685
[Reference]: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
2Serine PhosphorylationBrain cancer/tumorUS29122975685
[Reference]: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.
3Serine PhosphorylationColon cancer/carcinomaUS29122975685
[Reference]: PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 17)
(view all)
rs11906854; Migraine - clinic-based; migraine
rs17430100; Protein C levels; protein C deficiency
rs6060612; Common traits (Other); Null
rs17345771; Protein C levels; protein C deficiency
rs2425168; Protein C levels; protein C deficiency
rs2425173; Protein C levels; protein C deficiency

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 33)
(view all)
103       CWSDCRFYPAKVTAV     dbPAF
116       AVNKDGTYTVKFYDG     dbPAF
158       TDHKSLSSSPDKREK     dbPAF
159       DHKSLSSSPDKREKF     dbPAF
209       CSEKGKVSEKSLPKN     dbPAF
225       KEDKENISENDREYS     dbPAF
Acetylation
(count: 13)
(view all)
205       GKLICSEKGKVSEKS     PLMD
211       EKGKVSEKSLPKNEK     PLMD
299       KGCEVPLKRPRLDKN     PLMD
321       NYSENTDKDLSRRRS     PLMD
467       LKFFRKAKLLHYHMK     PLMD
491       EPEESPGKRHVQTRG     PLMD
Ubiquitination
(count: 8)
(view all)
1002      QLLMDLGKVQQIALC     PLMD
180       TVNVKKDKEDKPLKT     PLMD
183       VKKDKEDKPLKTEKR     PLMD
48        GKVLIHFKRWNHRYD     PLMD
713       GFKYWYDKEWLSRGH     PLMD
818       TLNGAVEKPRPLALP     PLMD
Sumoylation
(count: 3)
240       GDAQVDKKPENDIVK     PLMD
803       PVTDTRSKEEAPSYR     PLMD
854       YYPAVEQKLVVETRG     PLMD
Glycation
(count: 1)
818       TLNGAVEKPRPLALP     PLMD
Methylation
(count: 1)
177       RKATVNVKKDKEDKP     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource