| Tag | Content |
|---|---|
| UniProt Accession | MKNK1_HUMAN; Q9BUB5; |
| Entrez ID | 8569 |
| GenBank Protein ID | NM_001135553.2; NM_003684.5; NM_198973.3; XM_006711000.1; XM_017002659.1; |
| GenBank Nucleotide ID | NP_001129025.1; NP_003675.2; NP_945324.1; XP_006711063.1; XP_016858148.1; |
| Protein Name | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) |
| Gene Name | MKNK1; MNK1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. |
| Sequence (Fasta) | MVSSQKLEKP IEMGSSEPLP IADGDRRRKK KRRGRATDSL PGKFEDMYKL TSELLGEGAY 60 AKVQGAVSLQ NGKEYAVKII EKQAGHSRSR VFREVETLYQ CQGNKNILEL IEFFEDDTRF 120 YLVFEKLQGG SILAHIQKQK HFNEREASRV VRDVAAALDF LHTKDKVSLC HLGWSAMAPS 180 GLTAAPTSLG SSDPPTSASQ VAGTTGIAHR DLKPENILCE SPEKVSPVKI CDFDLGSGMK 240 LNNSCTPITT PELTTPCGSA EYMAPEVVEV FTDQATFYDK RCDLWSLGVV LYIMLSGYPP 300 FVGHCGADCG WDRGEVCRVC QNKLFESIQE GKYEFPDKDW AHISSEAKDL ISKLLVRDAK 360 QRLSAAQVLQ HPWVQGQAPE KGLPTPQVLQ RNSSTMDLTL FAAEAIALNR QLSQHEENEL 420 AEEPEALADG LCSMKLSPPC KSRLARRRAL AQAGRGEDRS PPTAL 466 |
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| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D019966 ; Substance-Related Disorders |
| GWASdb (count: 1) | rs1054743; Type 2 diabetes; type 2 diabetes mellitus |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 15) (view all) | 148 HFNEREASRVVRDVA dbPAF
191 AAPTSLGSSDPPTSA dbPAF 221 PENILCESPEKVSPV dbPAF 226 CESPEKVSPVKICDF dbPAF 237 ICDFDLGSGMKLNNS dbPAF 250 NSCTPITTPELTTPC dbPAF |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |