| Tag | Content |
|---|---|
| UniProt Accession | SIN1_HUMAN; Q9BPZ7; |
| Entrez ID | 79109 |
| GenBank Protein ID | NM_001006617.1; NM_001006618.1; NM_001006619.1; NM_001006620.1; NM_001006621.1; NM_024117.3; XM_011519010.2; XM_017015126.1; XM_017015127.1; |
| GenBank Nucleotide ID | NP_001006618.1; NP_001006619.1; NP_001006620.1; NP_001006621.1; NP_001006622.1; NP_077022.1; XP_011517312.1; XP_016870615.1; XP_016870616.1; |
| Protein Name | Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) |
| Gene Name | MAPKAP1; MIP1; SIN1 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activ(view all) |
| Sequence (Fasta) | MAFLDNPTII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK IHPPSMPGDS GSEIQGSNGE 60 TQGYVYAQSV DITSSWDFGI RRRSNTAQRL ERLRKERQNQ IKCKNIQWKE RNSKQSAQEL 120 KSLFEKKSLK EKPPISGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY 180 LPLHSSQDRL LPMTVVTMAS ARVQDLIGLI CWQYTSEGRE PKLNDNVSAY CLHIAEDDGE 240 VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLTSKESLF VRINAAHGFS LIQVDNTKVT 300 MKEILLKAVK RRKGSQKVSG PQYRLEKQSE PNVAVDLDST LESQSAWEFC LVRENSSRAD 360 GVFEEDSQID IATVQDMLSS HHYKSFKVSM IHRLRFTTDV QLGISGDKVE IDPVTNQKAS 420 TKFWIKQKPI SIDSDLLCAC DLAEEKSPSH AIFKLTYLSN HDYKHLYFES DAATVNEIVL 480 KVNYILESRA STARADYFAQ KQRKLNRRTS FSFQKEKKSG QQ 523 |
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| Database | Annotation |
|---|---|
| GWASdb (count: 12) (view all) | rs7023669; Smoking cessation; nicotine dependence
rs10986769; Progranulin levels; frontotemporal dementia rs10986769; Myocardial infarction; myocardial infarction rs1891034; Smoking cessation; nicotine dependence rs522894; Type 2 diabetes; type 2 diabetes mellitus rs522894; Smoking cessation; nicotine dependence |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 17) (view all) | 128 KSLFEKKSLKEKPPI dbPAF
140 PPISGKQSILSVRLE dbPAF 143 SGKQSILSVRLEQCP dbPAF 161 NNPFNEYSKFDGKGH dbPAF 185 DVYLPLHSSQDRLLP dbPAF 186 VYLPLHSSQDRLLPM dbPAF |
| Ubiquitination (count: 3) | 166 EYSKFDGKGHVGTTA PLMD
276 SSPGLTSKESLFVRI PLMD 501 RADYFAQKQRKLNRR PLMD |
| Network | Interaction | ||
|---|---|---|---|
| A | B | Source | |