Q99JB6

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	FOXP3_MOUSE; Q99JB6;
Entrez ID	20371
GenBank Protein ID	NM_001199347.1; NM_001199348.1; NM_054039.2;
GenBank Nucleotide ID	NP_001186276.1; NP_001186277.1; NP_473380.1;
Protein Name	Forkhead box protein P3 (Scurfin) [Cleaved into: Forkhead box protein P3, C-terminally processed; Forkhead box protein P3 41 kDa form]
Gene Name	Foxp3
Organism	Mus musculus
NCBI Taxa ID	10090
Functional Description	Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppress(view all) Functional Description Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (By similarity). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (By similarity). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (PubMed:19696312).
Sequence (Fasta)	MPNPRPAKPM APSLALGPSP GVLPSWKTAP KGSELLGTRG SGGPFQGRDL RSGAHTSSSL 60 NPLPPSQLQL PTVPLVMVAP SGARLGPSPH LQALLQDRPH FMHQLSTVDA HAQTPVLQVR 120 PLDNPAMISL PPPSAATGVF SLKARPGLPP GINVASLEWV SREPALLCTF PRSGTPRKDS 180 NLLAAPQGSY PLLANGVCKW PGCEKVFEEP EEFLKHCQAD HLLDEKGKAQ CLLQREVVQS 240 LEQQLELEKE KLGAMQAHLA GKMALAKAPS VASMDKSSCC IVATSTQGSV LPAWSAPREA 300 PDGGLFAVRR HLWGSHGNSS FPEFFHNMDY FKYHNMRPPF TYATLIRWAI LEAPERQRTL 360 NEIYHWFTRM FAYFRNHPAT WKNAIRHNLS LHKCFVRVES EKGAVWTVDE FEFRKKRSQR 420 PNKCSNPCP Fasta Sequence >Q99JB6\|Foxp3\|Mus musculus (Mouse) MPNPRPAKPMAPSLALGPSPGVLPSWKTAPKGSELLGTRGSGGPFQGRDLRSGAHTSSSLNPLPPSQLQLPTVPLVMVAPSGARLGPSPHLQALLQDRPHFMHQLSTVDAHAQTPVLQVRPLDNPAMISLPPPSAATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPRSGTPRKDSNLLAAPQGSYPLLANGVCKWPGCEKVFEEPEEFLKHCQADHLLDEKGKAQCLLQREVVQSLEQQLELEKEKLGAMQAHLAGKMALAKAPSVASMDKSSCCIVATSTQGSVLPAWSAPREAPDGGLFAVRRHLWGSHGNSSFPEFFHNMDYFKYHNMRPPFTYATLIRWAILEAPERQRTLNEIYHWFTRMFAYFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDEFEFRKKRSQRPNKCSNPCP

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Threonine Phosphorylation	Crohn's disease		U		23853094
1	[Reference]: Foxp3 protein stability is regulated by cyclin-dependent kinase 2.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 6)	MESH:D001172 ; Arthritis, Rheumatoid MESH:D001943 ; Breast Neoplasms MESH:D003922 ; Diabetes Mellitus, Type 1 MESH:C580192 ; Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome MESH:D015459 ; Leukemia-Lymphoma, Adult T-Cell MESH:D011085 ; Polycystic Ovary Syndrome

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 4)	175 CTFPRSGTPRKDSNL dbPAF 19 PSLALGPSPGVLPSW dbPAF 33 WKTAPKGSELLGTRG dbPAF 41 ELLGTRGSGGPFQGR dbPAF