Q99801

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession NKX31_HUMAN; Q99801;
Entrez ID 4824
GenBank Protein ID NM_001256339.1; NM_006167.3;
GenBank Nucleotide ID NP_001243268.1; NP_006158.2;
Protein Name Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
Gene Name NKX3-1; NKX3.1; NKX3A
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Sequence
(Fasta)
MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP 60
EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP 120
KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK 180
RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW 235

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationProstate cancer/carcinoma/adenocarcinomaNS4811980664
[Reference]: Substitution of cysteine for arginine 52 or of alanine for serine 48 (S48A) reduced phosphorylation at serine 48 in vitro and in vivo.We conclude that the polymorphic NKX3.1 allele codes for a variant protein with altered DNA binding activity that may affect prostate cancer risk.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:D011471 ; Prostatic Neoplasms

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 10)
(view all)
134       SRAAFSHTQVIELER     dbPAF
166       KNLKLTETQVKIWFQ     dbPAF
185       KTKRKQLSSELGDLE     dbPAF
186       TKRKQLSSELGDLEK     dbPAF
195       LGDLEKHSSLPALKE     dbPAF
196       GDLEKHSSLPALKEE     dbPAF
Ubiquitination
(count: 2)
162       AHLAKNLKLTETQVK     PLMD
182       RRYKTKRKQLSSELG     PLMD