Tag | Content |
---|---|
UniProt Accession | NKX31_HUMAN; Q99801; |
Entrez ID | 4824 |
GenBank Protein ID | NM_001256339.1; NM_006167.3; |
GenBank Nucleotide ID | NP_001243268.1; NP_006158.2; |
Protein Name | Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A) |
Gene Name | NKX3-1; NKX3.1; NKX3A |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
Sequence (Fasta) | MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP 60 EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP 120 KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK 180 RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW 235 |
|
Database | Annotation |
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CTD (Curated) (count: 1) | MESH:D011471 ; Prostatic Neoplasms |
PTM | Modification Sites |
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Phosphorylation (count: 10) (view all) | 134 SRAAFSHTQVIELER dbPAF
166 KNLKLTETQVKIWFQ dbPAF 185 KTKRKQLSSELGDLE dbPAF 186 TKRKQLSSELGDLEK dbPAF 195 LGDLEKHSSLPALKE dbPAF 196 GDLEKHSSLPALKEE dbPAF |
Ubiquitination (count: 2) | 162 AHLAKNLKLTETQVK PLMD
182 RRYKTKRKQLSSELG PLMD |