Q99801

PTMD Annotation Information

※ Protein Information

Tag	Content
UniProt Accession	NKX31_HUMAN; Q99801;
Entrez ID	4824
GenBank Protein ID	NM_001256339.1; NM_006167.3;
GenBank Nucleotide ID	NP_001243268.1; NP_006158.2;
Protein Name	Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
Gene Name	NKX3-1; NKX3.1; NKX3A
Organism	Homo sapiens
NCBI Taxa ID	9606
Functional Description	Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Functional Description Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Sequence (Fasta)	MLRVPEPRPG EAKAEGAAPP TPSKPLTSFL IQDILRDGAQ RQGGRTSSQR QRDPEPEPEP 60 EPEGGRSRAG AQNDQLSTGP RAAPEEAETL AETEPERHLG SYLLDSENTS GALPRLPQTP 120 KQPQKRSRAA FSHTQVIELE RKFSHQKYLS APERAHLAKN LKLTETQVKI WFQNRRYKTK 180 RKQLSSELGD LEKHSSLPAL KEEAFSRASL VSVYNSYPYY PYLYCVGSWS PAFW 235 Fasta Sequence >Q99801\|NKX3-1; NKX3.1; NKX3A\|Homo sapiens (Human) MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGGRTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSYLLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKNLKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYPYYPYLYCVGSWSPAFW

※ PTM-Disease Association

Num	PTM	Disease	Cell Type	Type	PTM Site	PMID
1	Serine Phosphorylation	Prostate cancer/carcinoma/adenocarcinoma		N	S48	11980664
1	[Reference]: Substitution of cysteine for arginine 52 or of alanine for serine 48 (S48A) reduced phosphorylation at serine 48 in vitro and in vivo.We conclude that the polymorphic NKX3.1 allele codes for a variant protein with altered DNA binding activity that may affect prostate cancer risk.

※ Disease Cross-ref Annotation

Database	Annotation
CTD (Curated) (count: 1)	MESH:D011471 ; Prostatic Neoplasms

※ PTM Sites

PTM	Modification Sites
Phosphorylation (count: 10) (view all)	134 SRAAFSHTQVIELER dbPAF 166 KNLKLTETQVKIWFQ dbPAF 185 KTKRKQLSSELGDLE dbPAF 186 TKRKQLSSELGDLEK dbPAF 195 LGDLEKHSSLPALKE dbPAF 196 GDLEKHSSLPALKEE dbPAF 222 NSYPYYPYLYCVGSW dbPAF 48 RQGGRTSSQRQRDPE dbPAF 89 AAPEEAETLAETEPE dbPAF 93 EAETLAETEPERHLG dbPAF
Ubiquitination (count: 2)	162 AHLAKNLKLTETQVK PLMD 182 RRYKTKRKQLSSELG PLMD