| Tag | Content |
|---|---|
| UniProt Accession | SMAD5_HUMAN; Q99717; |
| Entrez ID | 4090 |
| GenBank Protein ID | NM_001001419.2; NM_001001420.2; NM_005903.6; XM_017009470.1; |
| GenBank Nucleotide ID | NP_001001419.1; NP_001001420.1; NP_005894.3; XP_016864959.1; |
| Protein Name | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) |
| Gene Name | SMAD5; MADH5 |
| Organism | Homo sapiens |
| NCBI Taxa ID | 9606 |
| Functional Description | Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD). |
| Sequence (Fasta) | MTSMASLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME ELEKALSSPG 60 QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLDIC EFPFGSKQKE 120 VCINPYHYKR VESPVLPPVL VPRHNEFNPQ HSLLVQFRNL SHNEPHMPQN ATFPDSFHQP 180 NNTPFPLSPN SPYPPSPASS TYPNSPASSG PGSPFQLPAD TPPPAYMPPD DQMGQDNSQP 240 MDTSNNMIPQ IMPSISSRDV QPVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT 300 DPSNNKSRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD SSIFVQSRNC 360 NFHHGFHPTT VCKIPSSCSL KIFNNQEFAQ LLAQSVNHGF EAVYELTKMC TIRMSFVKGW 420 GAEYHRQDVT STPCWIEIHL HGPLQWLDKV LTQMGSPLNP ISSVS 466 |
|
||||||||||||||||||||
| Database | Annotation |
|---|---|
| CTD (Curated) (count: 1) | MESH:D003924 ; Diabetes Mellitus, Type 2 |
| DisGeNet (Curated) (count: 2) | C0011860; Diabetes Mellitus, Non-Insulin-Dependent
C0036341; Schizophrenia |
| GWASdb (count: 21) (view all) | rs3764941; Parkinson's disease; Parkinson's disease
rs10085013; Parkinson's disease; Parkinson's disease rs6596284; Parkinson's disease; Parkinson's disease rs7356756; Parkinson's disease; Parkinson's disease rs6596287; Parkinson's disease; Parkinson's disease rs6596288; Bipolar disorder and schizophrenia; bipolar disorder|schizophrenia |
| PTM | Modification Sites |
|---|---|
| Phosphorylation (count: 12) (view all) | 12 ASLFSFTSPAVKRLL dbPAF
128 VCINPYHYKRVESPV dbPAF 133 YHYKRVESPVLPPVL dbPAF 152 NEFNPQHSLLVQFRN dbPAF 188 NNTPFPLSPNSPYPP dbPAF 462 GSPLNPISSVS**** dbPAF |
| Ubiquitination (count: 2) | 306 FTDPSNNKSRFCLGL PLMD
64 SSPGQPSKCVTIPRS PLMD |
| Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||