Q99612

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession KLF6_HUMAN; Q99612;
Entrez ID 1316
GenBank Protein ID NM_001160124.1; NM_001160125.1; NM_001300.5;
GenBank Nucleotide ID NP_001153596.1; NP_001153597.1; NP_001291.3;
Protein Name Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9)
Gene Name KLF6; BCD1; COPEB; CPBP; ST12
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionTranscriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
Sequence
(Fasta)
MDVLPMCSIF QELQIVHETG YFSALPSLEE YWQQTCLELE RYLQSEPCYV SASEIKFDSQ 60
EDLWTKIILA REKKEESELK ISSSPPEDTL ISPSFCYNLE TNSLNSDVSS ESSDSSEELS 120
PTAKFTSDPI GEVLVSSGKL SSSVTSTPPS SPELSREPSQ LWGCVPGELP SPGKVRSGTS 180
GKPGDKGNGD ASPDGRRRVH RCHFNGCRKV YTKSSHLKAH QRTHTGEKPY RCSWEGCEWR 240
FARSDELTRH FRKHTGAKPF KCSHCDRCFS RSDHLALHMK RHL 284

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1AcetylationProstate cancer/carcinoma/adenocarcinomaNK20916230382
[Reference]: A single lysine-to-arginine point mutation (K209R) derived from prostate cancer reduces acetylation of KLF6 and abrogates its capacity to up-regulate endogenous p21(WAF1/cip1) and reduce cell proliferation.

※ Disease Cross-ref Annotation

DatabaseAnnotation
Cancer Gene Census
prostate, glioma
CTD (Curated)
(count: 3)
MESH:D008106 ; Liver Cirrhosis, Experimental
MESH:D011471 ; Prostatic Neoplasms
MESH:D013274 ; Stomach Neoplasms
DisGeNet (Curated)
(count: 6)
C0023893; Liver Cirrhosis, Experimental
C0033578; Prostatic Neoplasms
C0038356; Stomach Neoplasms
C0376358; Malignant neoplasm of prostate
C0544886; Somatic mutation
C0699791; Stomach Carcinoma
HGMD
(count: 2)
CM065289; Prostate cancer ?; Missense/nonsense
CS051259; Prostate cancer, risk, association with; Splicing
GWASdb
(count: 2)
rs1043003; Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption); hypertension
rs1043003; Cholesterol; arteriosclerosis|coronary artery disease|lipid metabolism disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 7)
(view all)
146       KLSSSVTSTPPSSPE     dbPAF
147       LSSSVTSTPPSSPEL     dbPAF
150       SVTSTPPSSPELSRE     dbPAF
151       VTSTPPSSPELSREP     dbPAF
171       CVPGELPSPGKVRSG     dbPAF
223       HLKAHQRTHTGEKPY     dbPAF
Acetylation
(count: 1)
209       CHFNGCRKVYTKSSH     PLMD
Ubiquitination
(count: 1)
66        SQEDLWTKIILAREK     PLMD
Sumoylation
(count: 1)
73        KIILAREKKEESELK     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource
A2ABF9Q99612HPRD; MINT
O15379Q99612HPRD
O43474Q99612HPRD
O95445Q99612HPRD; IntAct; MINT
P04637Q99612HPRD
P08047Q99612HPRD
Q12789Q99612HPRD; IntAct; MINT
Q14181Q99612HPRD; IntAct; MINT
Q96KQ7Q99612IntAct
Q99612Q9HCU4HPRD; IntAct; MINT
Q99612Q9NRX1HPRD; IntAct; MINT