Tag | Content |
---|---|
UniProt Accession | RING2_HUMAN; Q99496; |
Entrez ID | 6045 |
GenBank Protein ID | NM_007212.3; XM_011509851.2; XM_011509852.2; |
GenBank Nucleotide ID | NP_009143.1; XP_011508153.1; XP_011508154.1; |
Protein Name | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiqui |
Gene Name | RNF2; BAP1; DING; HIPI3; RING1B |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG(view all) |
Sequence (Fasta) | MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN 60 TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY 120 EAHQERVLAR INKHNNQQAL SHSIEEGLKI QAMNRLQRGK KQQIENGSGA EDNGDSSHCS 180 NASTHSNQEA GPSNKRTKTS DDSGLELDNN NAAMAIDPVM DGASEIELVF RPHPTLMEKD 240 DSAQTRYIKT SGNATVDHLS KYLAVRLALE ELRSKGESNQ MNLDTASEKQ YTIYIATASG 300 QFTVLNGSFS LELVSEKYWK VNKPMELYYA PTKEHK 337 |
|
Database | Annotation |
---|---|
GWASdb (count: 1) | rs34982714; Urinary metabolites; kidney disease |
PTM | Modification Sites |
---|---|
Phosphorylation (count: 15) (view all) | 116 LISKIYPSRDEYEAH dbPAF
120 IYPSRDEYEAHQERV dbPAF 143 NQQALSHSIEEGLKI dbPAF 168 KQQIENGSGAEDNGD dbPAF 176 GAEDNGDSSHCSNAS dbPAF 183 SSHCSNASTHSNQEA dbPAF |
Acetylation (count: 2) | 249 SAQTRYIKTSGNATV PLMD
275 ALEELRSKGESNQMN PLMD |
Ubiquitination (count: 6) | 149 HSIEEGLKIQAMNRL PLMD
249 SAQTRYIKTSGNATV PLMD 261 ATVDHLSKYLAVRLA PLMD 275 ALEELRSKGESNQMN PLMD 320 LVSEKYWKVNKPMEL PLMD 323 EKYWKVNKPMELYYA PLMD |
Sumoylation (count: 1) | 323 EKYWKVNKPMELYYA PLMD |
Network | Interaction | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | B | Source | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|