Tag | Content |
---|---|
UniProt Accession | PRPK_HUMAN; Q96S44; |
Entrez ID | 112858 |
GenBank Protein ID | |
GenBank Nucleotide ID | |
Protein Name | TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase) |
Gene Name | TP53RK; C20orf64; PRPK |
Organism | Homo sapiens |
NCBI Taxa ID | 9606 |
Functional Description | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. |
Sequence (Fasta) | MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK 60 HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV 120 TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV 180 LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD 240 EVRLRGRKRS MVG 254 |
|
Database | Annotation |
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CTD (Curated) (count: 1) | MESH:C537548 ; Galloway Mowat syndrome |
GWASdb (count: 1) | rs11550540; Suicide attempts in bipolar disorder; bipolar disorder |
PTM | Modification Sites |
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Phosphorylation (count: 9) (view all) | 129 VRDYIQSTMETEKTP dbPAF
132 YIQSTMETEKTPQGL dbPAF 135 STMETEKTPQGLSNL dbPAF 140 EKTPQGLSNLAKTIG dbPAF 201 EDKGVDLYVLEKAFL dbPAF 250 RLRGRKRSMVG**** dbPAF |
Ubiquitination (count: 4) | 134 QSTMETEKTPQGLSN PLMD
144 QGLSNLAKTIGQVLA PLMD 238 KARPVLKKLDEVRLR PLMD 40 LSGLELVKQGAEARV PLMD |
Network | Interaction | ||
---|---|---|---|
A | B | Source | |