Q96S44

PTMD Annotation Information


※ Protein Information

Tag Content
UniProt Accession PRPK_HUMAN; Q96S44;
Entrez ID 112858
GenBank Protein ID
GenBank Nucleotide ID
Protein Name TP53-regulating kinase (EC 2.7.11.1) (Atypical serine/threonine protein kinase TP53RK) (EKC/KEOPS complex subunit TP53RK) (EC 3.6.-.-) (Nori-2) (p53-related protein kinase)
Gene Name TP53RK; C20orf64; PRPK
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionComponent of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Sequence
(Fasta)
MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK 60
HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV 120
TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV 180
LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD 240
EVRLRGRKRS MVG 254

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Serine PhosphorylationColon cancer/carcinomaUS25028412249
[Reference]: We identified p53-related protein kinase (PRPK) as a new substrate of TOPK. TOPK binds with and phosphorylates PRPK at Ser250 in vitro and ex vivo.

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)
MESH:C537548 ; Galloway Mowat syndrome
GWASdb
(count: 1)
rs11550540; Suicide attempts in bipolar disorder; bipolar disorder

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 9)
(view all)
129       VRDYIQSTMETEKTP     dbPAF
132       YIQSTMETEKTPQGL     dbPAF
135       STMETEKTPQGLSNL     dbPAF
140       EKTPQGLSNLAKTIG     dbPAF
201       EDKGVDLYVLEKAFL     dbPAF
250       RLRGRKRSMVG****     dbPAF
Ubiquitination
(count: 4)
134       QSTMETEKTPQGLSN     PLMD
144       QGLSNLAKTIGQVLA     PLMD
238       KARPVLKKLDEVRLR     PLMD
40        LSGLELVKQGAEARV     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource