Q96I25

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession SPF45_HUMAN; Q96I25;
Entrez ID 84991
GenBank Protein ID NM_001145547.1; NM_032905.4;
GenBank Nucleotide ID NP_001139019.1; NP_116294.1;
Protein Name Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)
Gene Name RBM17; SPF45
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionSplice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.
Sequence
(Fasta)		MSLYDDLGVE TSDSKTEGWS KNFKLLQSQL QVKKAALTQA KSQRTKQSTV LAPVIDLKRG 60
GSSDDRQIVD TPPHVAAGLK DPVPSGFSAG EVLIPLADEY DPMFPNDYEK VVKRQREERQ 120
RQRELERQKE IEEREKRRKD RHEASGFARR PDPDSDEDED YERERRKRSM GGAAIAPPTS 180
LVEKDKELPR DFPYEEDSRP RSQSSKAAIP PPVYEEQDRP RSPTGPSNSF LANMGGTVAH 240
KIMQKYGFRE GQGLGKHEQG LSTALSVEKT SKRGGKIIVG DATEKDASKK SDSNPLTEIL 300
KCPTKVVLLR NMVGAGEVDE DLEVETKEEC EKYGKVGKCV IFEIPGAPDD EAVRIFLEFE 360
RVESAIKAVV DLNGRYFGGR VVKACFYNLD KFRVLDLAEQ V 402

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1PhosphorylationOvarian cancer/carcinomaSKOV-3 cell lineP23519612
[Reference]: Collectively, these results show that SPF45 overexpression promoted cell migration and invasion in a phosphorylation-dependent manner

※ Disease Cross-ref Annotation

DatabaseAnnotation
CTD (Curated)
(count: 1)		MESH:D020754 ; Spinocerebellar Ataxias
GWASdb
(count: 1)		rs8463; Multiple complex diseases; Null

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 31)
(view all)		 145       RKDRHEASGFARRPD     dbPAF
155       ARRPDPDSDEDEDYE     dbPAF
161       DSDEDEDYERERRKR     dbPAF
169       ERERRKRSMGGAAIA     dbPAF
179       GAAIAPPTSLVEKDK     dbPAF
180       AAIAPPTSLVEKDKE     dbPAF
Acetylation
(count: 16)
(view all)		 184       PPTSLVEKDKELPRD     PLMD
21        SKTEGWSKNFKLLQS     PLMD
24        EGWSKNFKLLQSQLQ     PLMD
241       MGGTVAHKIMQKYGF     PLMD
245       VAHKIMQKYGFREGQ     PLMD
256       REGQGLGKHEQGLST     PLMD
Ubiquitination
(count: 5)		 184       PPTSLVEKDKELPRD     PLMD
256       REGQGLGKHEQGLST     PLMD
327       EDLEVETKEECEKYG     PLMD
33        LQSQLQVKKAALTQA     PLMD
46        QAKSQRTKQSTVLAP     PLMD
Glycation
(count: 2)		 289       ATEKDASKKSDSNPL     PLMD
327       EDLEVETKEECEKYG     PLMD

※ Protein-Protein Interaction

NetworkInteraction
ABSource