Q96BF3

PTMD Annotation Information

※ Protein Information

Tag Content
UniProt Accession TMIG2_HUMAN; Q96BF3;
Entrez ID 126259
GenBank Protein ID NM_001169126.1; NM_001308232.1; NM_144615.2;
GenBank Nucleotide ID NP_001162597.1; NP_001295161.1; NP_653216.2;
Protein Name Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
Gene Name TMIGD2; CD28H; IGPR1; UNQ3059/PRO9879
Organism Homo sapiens
NCBI Taxa ID 9606
Functional DescriptionPlays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Sequence
(Fasta)		MGSPGMVLGL LVQIWALQEA SSLSVQQGPN LLQVRQGSQA TLVCQVDQAT AWERLRVKWT 60
KDGAILCQPY ITNGSLSLGV CGPQGRLSWQ APSHLTLQLD PVSLNHSGAY VCWAAVEIPE 120
LEEAEGNITR LFVDPDDPTQ NRNRIASFPG FLFVLLGVGS MGVAAIVWGA WFWGRRSCQQ 180
RDSGNSPGNA FYSNVLYRPR GAPKKSEDCS GEGKDQRGQS IYSTSFPQPA PRQPHLASRP 240
CPSPRPCPSP RPGHPVSMVR VSPRPSPTQQ PRPKGFPKVG EE 283

※ PTM-Disease Association

NumPTMDiseaseCell TypeTypePTM SitePMID
1Tyrosine PhosphorylationNeuroblastomaUY24349301
[Reference]: Increased in NB10 cells (MYCN amplified neuroblastoma line) compared to NPC cells (normal neural crest line)

※ Disease Cross-ref Annotation

DatabaseAnnotation
GWASdb
(count: 1)		rs888932; Response to cytadine analogues (cytosine arabinoside); cancer

※ PTM Sites

PTM Modification Sites
Phosphorylation
(count: 8)
(view all)		 192       NSPGNAFYSNVLYRP     dbPAF
193       SPGNAFYSNVLYRPR     dbPAF
197       AFYSNVLYRPRGAPK     dbPAF
220       GKDQRGQSIYSTSFP     dbPAF
222       DQRGQSIYSTSFPQP     dbPAF
224       RGQSIYSTSFPQPAP     dbPAF